The acute respiratory distress syndrome (ARDS) is an important cause of acute respiratory
failure that is often associated with multiple organ failure. Several clinical disorders can …

Inflammatory bowel disease (IBD) is a chronic inflammatory disorder with rising incidence.
Diseased tissues are heavily vascularized. Surprisingly, the pathogenic impact of the …

In various human diseases, an increase in capillary permeability to proteins leads to the loss
of protein-rich fluid from the intravascular to the interstitial space. Although sepsis is the …

Cadherin family includes lists of transmembrane glycoproteins which mediate calcium-
dependent cell-cell adhesion. Cadherin-mediated adhesion regulates cell growth and …

The meningeal lymphatic network enables the drainage of cerebrospinal fluid (CSF) and
facilitates the removal of central nervous system (CNS) waste. During aging and in …

Vascular endothelial cells (ECs) are exposed to hemodynamic forces, which modulate EC
functions and vascular biology/pathobiology in health and disease. The flow patterns and …

Neutrophils provide first line of host defense against bacterial infections utilizing glycolysis
for their effector functions. How glycolysis and its major byproduct lactate are triggered in …

Endothelial cells are a constitutive part of the heart and vasculature and form a crucial link
between the cardiovascular system and the immune system. Besides their commonly …

Increased pulmonary microvessel pressure experienced in left heart failure, head trauma, or
high altitude can lead to endothelial barrier disruption referred to as capillary “stress failure” …

Endothelial cells, which form the inner cellular lining of blood vessels and lymphatics,
display remarkable heterogeneity in structure and function. This is the first of a 2-part review …