Inflammation is a complex and potentially life-threatening condition that involves the
participation of a variety of chemical mediators, signaling pathways, and cell types. The …

How vascular endothelial growth factor (VEGF) induces vascular permeability, its first
described function, remains poorly understood. Here, we provide evidence of a novel …

Although vascular endothelial growth factor (VEGF) induces angiogenesis, it also disrupts
vascular barrier function in diseased tissues. Accordingly, VEGF expression in cancer and …

Vascular endothelial cadherin, VE-cadherin, mediates adhesion between endothelial cells
and may affect vascular morphogenesis via intracellular signaling, but the nature of these …

The endothelial cell (EC) lining of the pulmonary vasculature forms a semipermeable barrier
between the blood and the interstitium of the lung. Disruption of this barrier occurs during …

Intercellular junctions mediate adhesion and communication between adjoining cells.
Although formed by different molecules, tight junctions (TJs) and adherens junctions (AJs) …

The endothelium forms a selective semi-permeable barrier controlling bidirectional transfer
between blood vessel and irrigated tissues. This crucial function relies on the dynamic …

Endothelial junctions provide blood and lymph vessel integrity and are essential for the
formation of a vascular system. They control the extravasation of solutes, leukocytes and …

Vascular endothelial (VE)–protein tyrosine phosphatase (PTP) associates with VE-cadherin,
thereby supporting its adhesive activity and endothelial junction integrity. VE-PTP also …

Endothelial cells lining the vessel wall are connected by adherens, tight and gap junctions.
These junctional complexes are related to those found at epithelial junctions but with …