Microvascular endothelial injury and dysfunction during ischemic acute renal failure. The
pathophysiology of ischemic acute renal failure (ARF) appears to involve a complex …

Psoriasis pathogenesis is closely associated with disease‐inducing Th1 and Th17 cells. Yet,
several studies suggest that aberrant keratinocyte or endothelial cell signalling significantly …

E-cadherin controls a wide array of cellular behaviors including cell–cell adhesion,
differentiation and tissue development. Here we show that presenilin-1 (PS1), a protein …

Despite intense research into the pathogenesis of sepsis, the current therapy for this
devastating syndrome is primarily supportive and mortality remains high. The paucity of …

Inflammation is a basic pathological mechanism that underlies many diseases. An important
component of the inflammatory response is the passage of plasma components and …

Endothelial permeability depends on the integrity of intercellular junctions as well as
actomyosin-based cell contractility. Rho GTPases have been implicated in signalling by …

Endothelial cells form cell–cell adhesive structures, called adherens and tight junctions,
which maintain tissue integrity, but must be dynamic for leukocyte transmigration during the …

The endothelial cells forming the blood-brain barrier (BBB) are highly specialized to allow
precise control over the substances that leave or enter the brain. An elaborate network of …

Digital light processing (DLP) bioprinting is an emerging technology for three-dimensional
bioprinting (3DBP) owing to its high printing fidelity, fast fabrication speed, and higher …

In 1960, Dr Bayard Clarkson described a woman experiencing sporadic recurrent episodes
of shock and anasarca. Plasma from an acute attack induced a shock-like syndrome when …