When and where to make or break new blood vessel connections is the key to
understanding guided vascular patterning. VEGF-A stimulation and Dll4/Notch signaling …

Inspired by the adhesion strategy of marine mussels, self-polymerization of dopamine under
alkaline condition has been proven to be a simple and effective method for surface …

To determine whether leukocytes need to open endothelial cell contacts during
extravasation, we decided to generate mice with strongly stabilized endothelial junctions. To …

Taiwan experienced several epidemics of enterovirus 71 (EV71) infections, which were
associated with brainstem encephalitis (BE) and pulmonary edema (PE). To elucidate the …

Confluent endothelial cells respond poorly to the proliferative signals of VEGF. Comparing
isogenic endothelial cells differing for vascular endothelial cadherin (VE-cadherin) …

FTY720, a potent immunosuppressive agent, is phosphorylated in vivo into FTY720-P, a
high affinity agonist for sphingosine 1-phosphate (S1P) receptors. The effects of FTY720 on …

Leukocyte transendothelial migration (TEM) has been modeled as a multistep process
beginning with rolling adhesion, followed by firm adhesion, and ending with either …

Leukocyte adhesion to the endothelial cells lining the vessel wall and the subsequent
migration of the leukocytes into the underlying tissue are key elements of both innate and …

The regulation of endothelial cell contacts is of central importance for the barrier function of
the blood vessel wall and for the control of leukocyte extravasation. In addition, the plasticity …

The integrity of the endothelial monolayer is essential to blood vessel homeostasis and
active regulation of endothelial permeability. The FGF system plays important roles in a wide …