Molecular anatomy of intercellular junctions in brain endothelial and epithelial barriers: electron microscopist's view

AW Vorbrodt, DH Dobrogowska - Brain Research Reviews, 2003 - Elsevier
In this review, we have tried to summarize the current knowledge on the distribution of
important molecular components of intercellular junctions—both tight junctions (TJs) and …

Transmural flow modulates cell and fluid transport functions of lymphatic endothelium

DO Miteva, JM Rutkowski, JB Dixon, W Kilarski… - Circulation …, 2010 - Am Heart Assoc
Rationale: Lymphatic transport of peripheral interstitial fluid and dendritic cells (DCs) is
important for both adaptive immunity and maintenance of tolerance to self-antigens …

Disorders of vascular permeability

C Park-Windhol, PA D'Amore - Annual Review of Pathology …, 2016 - annualreviews.org
The endothelial barrier maintains vascular and tissue homeostasis and modulates many
physiological processes, such as angiogenesis. Vascular barrier integrity can be disrupted …

[HTML][HTML] VE‐PTP and VE‐cadherin ectodomains interact to facilitate regulation of phosphorylation and cell contacts

R Nawroth, G Poell, A Ranft, S Kloep… - The EMBO …, 2002 - embopress.org
VE‐cadherin is the essential adhesion molecule in endothelial adherens junctions, and the
regulation of protein tyrosine phosphorylation is thought to be important for the control of …

Stepping out of the flow: capillary extravasation in cancer metastasis

FL Miles, FL Pruitt, KL Van Golen… - Clinical & experimental …, 2008 - Springer
In order for cancer cells to successfully colonize a metastatic site, they must detach from the
primary tumor using extracellular matrix-degrading proteases, intravasate and survive in the …

[HTML][HTML] Stem cell trafficking in tissue development, growth, and disease

DJ Laird, UH von Andrian, AJ Wagers - Cell, 2008 - cell.com
Regulated movement of stem cells is critical for organogenesis during development and for
homeostasis and repair in adulthood. Here we analyze the biological significance and …

The role of VE-cadherin in vascular morphogenesis and permeability control

E Dejana, D Vestweber - Progress in molecular biology and translational …, 2013 - Elsevier
VE-cadherin is an endothelial-specific cadherin that is essential for the formation and
regulation of endothelial cell junctions. The adhesive function and expression levels of VE …

Adhesion and signaling molecules controlling the transmigration of leukocytes through endothelium

D Vestweber - Immunological reviews, 2007 - Wiley Online Library
Migration of leukocytes into tissue is a key element of innate and adaptive immunity. While
the capturing of leukocytes to the blood vessel wall is well understood, little is known about …

Monoclonal antibodies directed to different regions of vascular endothelial cadherin extracellular domain affect adhesion and clustering of the protein and modulate …

M Corada, F Liao, M Lindgren… - Blood, The Journal …, 2001 - ashpublications.org
Vascular endothelial cadherin (VE-cadherin) is an endothelial cell–specific cadherin that
plays an important role in the control of vascular organization. Blocking VE-cadherin …

Real-time imaging of vascular endothelial-cadherin during leukocyte transmigration across endothelium

SK Shaw, PS Bamba, BN Perkins… - The Journal of …, 2001 - journals.aai.org
Vascular endothelial-cadherin (VE-cadherin) is a component of the adherens junctions of
endothelial cells whose role in endothelial transmigration of leukocytes has been …