The vascular endothelial cell forms a semipermeable barrier between blood and interstitium.
Inflammatory mediators such as thrombin and histamine induce vascular leakage defined as …

Leukocyte migration from the blood into tissues is vital for immune surveillance and
inflammation. During this diapedesis of leukocytes, the leukocytes bind to endothelial cell …

Neutrophil emigration in the lung differs substantially from that in systemic vascular beds
where extravasation occurs primarily through postcapillary venules. Migration into the …

Acute respiratory distress syndrome (ARDS) was first described in 1967, and since then
there have been a large number of studies addressing its pathogenesis and therapies …

Using the Cre/loxP system we conditionally inactivated β-catenin in endothelial cells. We
found that early phases of vasculogenesis and angiogenesis were not affected in mutant …

A vast amount of work has been dedicated to the effects of shear flow and cytokines on
leukocyte transmigration. However, no studies have explored the effects of substrate …

Endothelium forms a physical barrier that separates blood from tissue. Communication
between blood and tissue occurs through the delivery of molecules and circulating …

Interleukin (IL)-33 is a novel member of the IL-1 family of cytokines that promotes Th2
responses in lymphocytes as well as the activation of both mast cells and eosinophils via the …

We have recently shown that vascular endothelial protein tyrosine phosphatase (VE-PTP),
an endothelial membrane protein, associates with VE-cadherin and is required for optimal …

Angiopoietin-1 (Ang1) and angiopoietin-2 (Ang2) have complex actions in angiogenesis
and vascular remodeling due to their effects on Tie2 receptor signaling. Ang2 blocks Ang1 …