Dysfunctional and leaky blood vessels resulting from disruption of the endothelial cell (EC)
barrier accompanies numerous diseases. The EC barrier is established through endothelial …

The role of renal microvascular endothelial cell injury in the pathophysiology of ischemic
acute renal failure (ARF) remains largely unknown. No consistent morphological alterations …

Tight regulation of the balance between apoptosis and survival is essential in angiogenesis.
The ETS transcription factor Erg is required for endothelial tube formation in vitro. Inhibition …

Increased endothelial permeability is the hallmark of inflammatory vascular edema.
Inflammatory mediators that bind to heptahelical G protein-coupled receptors trigger …

The integrity of the endothelium is dependent on cell-cell adhesion, which is mediated by
vascular-endothelial (VE)-cadherin. Proper VE-cadherin-mediated homotypic adhesion is, in …

As the primary physical barrier between blood and tissue compartments within the body,
blood vessel endothelial cells and integrity of the cell junctions connecting them must be …

This work examines how mechanical signals affect the barrier function and stability of
engineered human microvessels in microfluidic type I collagen gels. Constructs that were …

Endothelial cells are linked to each other through intercellular junctional complexes that
regulate the barrier and fence function of the vascular wall. The nature of these intercellular …

Angiogenesis is a key process involved in normal development and wound repair, as well
as ischemic heart and limb diseases, and atherosclerosis. Vascular endothelial growth …

Vascular permeability is a complex process involving the coordinated regulation of multiple
signaling pathways in the endothelial cell. It has long been documented that vascular …