Src-family tyrosine kinases are regulatory proteins that play a pivotal role in the
disorganization of cadherin-dependent cell–cell contacts. We previously showed that Src …

Objective: In sepsis, quiescent blood vessels become leaky and inflamed by mechanisms
that are incompletely understood. We hypothesized that angiopoietin-2, a partial antagonist …

The molecular and cellular pathways that support the maintenance and stability of tumor
neovessels are not well defined. The efficacy of microtubule-disrupting agents, such as …

Data collected during the past years indicate that AJ-and more specifically VE-cadherin play
an important role in endothelial cell biology. VE-cadherin may transfer information …

Vascular endothelial (VE)-cadherin in endothelial adherens junctions is an essential
component of the vascular barrier, critical for tissue homeostasis and implicated in diseases …

Metastasis, the major cause of cancer death, is a multistep process that requires interactions
between cancer cells and stromal cells and between cancer cells and extracellular matrix …

We have shown recently that vascular endothelial protein tyrosine phosphatase (VE-PTP),
an endothelial-specific membrane protein, associates with vascular endothelial (VE) …

OBJECTIVE—Increased vascular permeability due to alteration of the blood-retinal barrier
(BRB) is one of the major complications in early diabetes. The aim of the present study was …

Abstract Sphingosine 1-phosphate (S1P), a lipid mediator produced by sphingolipid
metabolism, promotes endothelial cell spreading, vascular maturation/stabilization, and …

The blood-brain barrier (BBB) is the one of the most robust physical barriers in the body,
comprised of tight junction (TJ) proteins in brain microvascular endothelial cells. The need …