The role of cardiac N-methyl-D-aspartate receptors in heart conditioning—effects on heart function and oxidative stress

N Govoruskina, V Jakovljevic, V Zivkovic… - Biomolecules, 2020 - mdpi.com
As well as the most known role of N-methyl-D-aspartate receptors (NMDARs) in the nervous
system, there is a plethora of evidence that NMDARs are also present in the cardiovascular …

Furin-mediated cleavage of LRP1 and increase in ICD of LRP1 after cerebral ischemia and after exposure of cultured neurons to NMDA

M Yamada, H Hayashi, K Suzuki, S Sato, D Inoue… - Scientific Reports, 2019 - nature.com
The N-methyl-D-aspartate (NMDA) receptor has been implicated in several
neurodegenerative diseases, including stroke. Low-density lipoprotein receptor-related …

Pairing of neonatal phencyclidine exposure and acute adolescent stress in male rats as a novel developmental model of schizophrenia

AA Moghadam, LR Vose, O Miry, XL Zhang… - Behavioural Brain …, 2021 - Elsevier
Improved understanding of the neurophysiological and neurochemical mechanisms
underlying schizophrenia is essential for the identification of biological markers and …

New insights into the crosstalk between NMDARs and iron: Implications for understanding pathology of neurological diseases

H Xu, H Jiang, J Xie - Frontiers in Molecular Neuroscience, 2017 - frontiersin.org
Both iron dyshomeostasis and N-methyl-D-aspartate receptors (NMDARs)-mediated
neurotoxicity have been shown to have an important role in neurological diseases such as …

Glutamate receptor endocytosis and signaling in neurological conditions

P Yadav, M Podia, SP Kumari, I Mani - Progress in Molecular Biology and …, 2023 - Elsevier
The non-essential amino acid glutamate acts as a major excitatory neurotransmitter and
plays a significant role in the central nervous system (CNS). It binds with two different types …

CRMP2-derived peptide ST2-104 (R9-CBD3) protects SH-SY5Y neuroblastoma cells against Aβ25-35-induced neurotoxicity by inhibiting the pCRMP2/NMDAR2B …

Y Ji, Y Hu, J Ren, R Khanna, Y Yao, Y Chen… - Chemico-Biological …, 2019 - Elsevier
Collapsin response mediator protein 2 (CRMP2), by regulating voltage-gated calcium
channel activity, is a crucial regulator of neuronal excitability. Hyperphosphorylation of …

Simulated dynamics of glycans on ligand-binding domain of NMDA receptors reveals strong dynamic coupling between glycans and protein core

AV Sinitskiy, VS Pande - Journal of Chemical Theory and …, 2017 - ACS Publications
N-Methyl-d-aspartate (NMDA) receptors, key neuronal receptors playing the central role in
learning and memory, are heavily glycosylated in vivo. Astonishingly little is known about the …

Low-frequency electroacupuncture alleviates chronic constrictive injury-induced mechanical allodynia by inhibiting NR2B upregulation in ipsilateral spinal dorsal horn …

W Zhao, Z Jiang, H Shi, L Xu, Y Yang… - Chinese Journal of …, 2019 - Springer
Objective To study the effects of electroacupuncture (EA) in chronic constrictive injury (CCI)
rat model and the expression of N-methyl-D-aspartate receptor type 2B (NR2B) in ipsilateral …

Optogenetic stimulation of the anterior cingulate cortex ameliorates autistic-like behaviors in rats induced by neonatal isolation, caudate putamen as a site for …

ES Sayed Javad Javaheri, MR Bigdeli, MI Zibaii… - NeuroMolecular …, 2019 - Springer
Epigenetic agents, such as neonatal isolation during neurodevelopmental period of life, can
change various regions of the brain. It may further induce psychological disorders such as …

Jacob, a synapto-nuclear protein messenger linking N-methyl-D-aspartate receptor activation to nuclear gene expression

KM Grochowska, J Bär, GM Gomes… - Frontiers in synaptic …, 2021 - frontiersin.org
Pyramidal neurons exhibit a complex dendritic tree that is decorated by a huge number of
spine synapses receiving excitatory input. Synaptic signals not only act locally but are also …