Therapeutic nuclease-albumin fusions and methods

JA Posada, C Gabel - US Patent 10,988,745, 2021 - Google Patents
The invention provides for hybrid nuclease-albumin mol ecules with increased
pharmacokinetic properties. The hybrid nuclease-albumin molecules of the invention have …

Compositions with modified nucleases targeted to viral nucleic acids and methods of use for prevention and treatment of viral diseases

JG Appelbaum, RI Salganik - US Patent 9,592,277, 2017 - Google Patents
Antiviral compositions comprising a modified nuclease, or a plurality of Such modified
nucleases having at least one non-natural amino acid residue substituted for a naturally …

Methods, systems, and devices for machines and machine states that facilitate modification of documents based on various corpora and/or modification data

E Brav, AJ Cohen, EKY Jung, RA Levien… - US Patent App. 14 …, 2015 - Google Patents
2017-02-09 Assigned to ELWHA LLC reassignment ELWHA LLC ASSIGNMENT OF
ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: COHEN …

Therapeutic nuclease compositions and methods

JA Ledbetter, M Hayden-Ledbetter, K Elkon… - US Patent …, 2015 - Google Patents
2014-05-21 Assigned to UNIVERSITY OF WASHINGTON reassignment UNIVERSITY OF
WASHINGTON ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …

Therapeutic nuclease compositions and methods

JA Ledbetter, M Hayden-Ledbetter, K Elkon… - US Patent …, 2018 - Google Patents
2015-05-19 Assigned to UNIVERSITY OF WASHINGTON reassignment UNIVERSITY OF
WASHINGTON ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …

Therapeutic nuclease compositions and methods

JA Ledbetter, M Hayden-Ledbetter, K Elkon… - US Patent …, 2019 - Google Patents
2012-06-27 Assigned to UNIVERSITY OF WASHINGTON reassignment UNIVERSITY OF
WASHINGTON ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …

Therapeutic nuclease compositions and methods

JA Ledbetter, M Hayden-Ledbetter, K Elkon… - US Patent …, 2017 - Google Patents
2014-10-17 Assigned to UNIVESITY OF WASHINGTON reassignment UNIVESITY OF
WASHINGTON ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …

Therapeutic nuclease compositions and methods

JA Ledbetter, M Hayden-Ledbetter, K Elkon… - US Patent …, 2022 - Google Patents
2017-08-21 Assigned to UNIVERSITY OF WASHINGTON THROUGH ITS CENTER FOR
COMMERCIALIZATION reassignment UNIVERSITY OF WASHINGTON THROUGH ITS …

Therapeutic nuclease compositions and methods

JA Ledbetter, M Hayden-Ledbetter, K Elkon… - US Patent …, 2021 - Google Patents
2019-04-11 Assigned to UNIVERSITY OF WASHINGTON reassignment UNIVERSITY OF
WASHINGTON ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR …

Compositions with modified nucleases targeted to viral nucleic acids and methods of use for prevention and treatment of viral diseases

JG Applebaum - US Patent 10,335,372, 2019 - Google Patents
Antiviral compositions comprising a modified nuclease, or a plurality of such modified
nucleases having at least one non-natural amino acid residue substituted for a naturally …