Transcriptional regulation and epigenetic mechanisms closely control gene expression
through diverse physiological and pathophysiological processes. These include the …

Summary SHH subgroup medulloblastoma (SHH-MB) is one of the most common malignant
pediatric tumors that arises in the cerebellum. Previously, we showed that RNA m 6 A …

Recent advances in stem cell biology have shed light on how normal stem and progenitor
cells can evolve to acquire malignant characteristics during tumorigenesis. The cancer …

Molecular subclassification is rapidly informing the clinical management of
medulloblastoma. However, the disease remains associated with poor outcomes and …

Purpose: Microarray studies indicate medulloblastoma comprises distinct molecular disease
subgroups, which offer potential for improved clinical management. Experimental Design …

Rhabdomyosarcoma is a pediatric tumor of skeletal muscle that expresses the myogenic
basic helix-loop-helix protein MyoD but fails to undergo terminal differentiation. Prior work …

Rhabdomyosarcoma is the most common soft-tissue sarcoma in children. While cytogenetic
abnormalities have been well characterized in this disease, aberrant epigenetic events such …

Recent advances in cancer genomics have revolutionized the characterization and
classification of medulloblastomas. According to the current WHO guidelines …

Abstract The Hedgehog (Hh) and wingless-Int1 (Wnt) pathways are important for tissue
patterning in the developing embryo. In adult tissue, both pathways are typically dormant but …

There is relatively little information concerning long-term alterations in DNA methylation
following exposure of plants to environmental stress. As little is known about the ratio of non …