Severe malaria: Biology, clinical manifestation, pathogenesis and consequences

SN Balaji, R Deshmukh, V Trivedi - Journal of Vector Borne …, 2020 - journals.lww.com
Every year, millions of people are infected with malaria, resulting in significant economic
losses to the developing and developed nations. The malaria parasite pursues a …

Circulating monocytes, tissue macrophages, and malaria

N Ozarslan, JF Robinson… - Journal of tropical medicine, 2019 - Wiley Online Library
Malaria is a significant cause of global morbidity and mortality. The Plasmodium parasite
has a complex life cycle with mosquito, liver, and blood stages. The blood stages can …

The impact of innate immunity on malaria parasite infection dynamics in rodent models

A Herbert Mainero, PJ Spence, SE Reece… - Frontiers in …, 2023 - frontiersin.org
Decades of research have probed the molecular and cellular mechanisms that control the
immune response to malaria. Yet many studies offer conflicting results on the functional …

The angiotensin II/AT1 receptor pathway mediates malaria-induced acute kidney injury

LS Silva, DB Peruchetti, RP Silva-Aguiar, TP Abreu… - PLoS …, 2018 - journals.plos.org
Malaria-induced acute kidney injury (MAKI) is a life-threatening complication of severe
malaria. Here, we investigated the potential role of the angiotensin II (Ang II)/AT1 receptor …

Characterising the effect of antimalarial drugs on the maturation and clearance of murine blood-stage Plasmodium parasites in vivo

DS Khoury, D Cromer, T Elliott, MSF Soon… - International journal for …, 2017 - Elsevier
The artemisinins are the first-line therapy for severe and uncomplicated malaria, since they
cause rapid declines in parasitemia after treatment. Despite this, in vivo mechanisms …

Involvement of Inflammatory Cytokines, Renal NaPi-IIa Cotransporter, and TRAIL Induced-Apoptosis in Experimental Malaria-Associated Acute Kidney Injury

GM Simião, KS Parreira, SG Klein, FB Ferreira… - Pathogens, 2024 - mdpi.com
The murine model of experimental cerebral malaria (ECM) induced by Plasmodium berghei
ANKA was used to investigate the relationship among pro-inflammatory cytokines …

Babesia microti Confers Macrophage-Based Cross-Protective Immunity Against Murine Malaria

A Efstratiou, EMS Galon, G Wang, K Umeda… - Frontiers in cellular …, 2020 - frontiersin.org
Malaria and babesiosis, the two primary intraerythrocytic protozoan diseases of humans,
have been reported in multiple cases of co-infection in endemic regions. As the geographic …

[HTML][HTML] Statin and aspirin use in parasitic infections as a potential therapeutic strategy: A narrative review

V Burgess, JD Maya - Revista Argentina de Microbiología, 2023 - Elsevier
Infections, including zoonoses, constitute a threat to human health due to the spread of
resistant pathogens. These diseases generate an inflammatory response controlled by a …

Conventional CD11chigh Dendritic Cells Are Important for T Cell Priming during the Initial Phase of Plasmodium yoelii Infection, but Are Dispensable at Later Time …

K Ueffing, H Abberger, AM Westendorf… - Frontiers in …, 2017 - frontiersin.org
Dendritic cells (DCs) are highly specialized antigen-presenting cells that orchestrate
adaptive immune responses to pathogens. During malaria infection pro-and anti …

The impact of innate immunity on malaria parasite infection dynamics

A Herbert-Mainero, PJ Spence, SE Reece, T Kamiya - bioRxiv, 2023 - biorxiv.org
Decades of research have investigated the molecular and cellular mechanisms that control
the immune response to malaria. Yet, many studies offer conflicting results on the functional …