This study aimed to evaluate the prevalence of vertebral fractures to investigate the
determinants of vertebral fracture risk in patients with COPD. The risk of vertebral fractures is …

Inhaled corticosteroid (ICS) therapy in combination with long-acting β-adrenergic agonists
represents the most important treatment for chronic airways diseases such as asthma and …

The use of inhaled corticosteroids has been associated with a dose-related increased risk of
fracture. This may be related to systemic absorption. However, several studies have found …

Although randomized controlled designs are considered the so-called gold standard in
medical trials and sit atop the hierarchy of evidence in evidence-based medicine, there are …

Glucocorticoids (GCs) are frequently prescribed for various inflammatory and/or life-
threatening conditions concerning many systems in the body. However, they can provoke …

Objectives. To study the fracture risk associated with the use of corticosteroids in any
formulation and administration. Design. Case–control study. Setting. Community‐based …

Osteoporosis is one of the systemic effects associated with chronic obstructive pulmonary
disease (COPD). Potential risk factors of osteoporosis may be due to the lifestyle, genetics …

This review summarizes the available evidence-based data that form the basis for
therapeutic intervention and covers the current status of glucocorticoid-induced osteoporosis …

Bone remodeling is regulated by systemic and local factors, and glucocorticoids are
hormones with a significant impact on the skeleton. Bone remodeling is tightly regulated …

Deleterious effect of oral corticosteroids on bone has been well documented, whereas this
remains debated for inhaled ones (ICS). Our objectives were to analyze the effects of ICS on …