Objective To determine the strength of association between the dose of inhaled
corticosteroids (ICS) and risk of non‐vertebral fracture in adults. Methods A systematic …

Background Ciclesonide is a novel inhaled corticosteroid developed for the treatment of
asthma. Objective To investigate the extent of oral absorption and bioavailability of …

We conducted a double blind, randomised, placebo-controlled, crossover study evaluating
the effects of halving inhaled steroid dosage plus salmeterol, or salmeterol and tiotropium …

Objective Our objective was to examine the effects of itraconazole on the pharmacokinetics
and cortisol‐suppressant activity of budesonide administered by inhalation. Methods In a …

Introduction Osteoporosis and fragility fractures are associated with corticosteroids which
are the mainstay treatment for asthma; however, these bone comorbidities within asthma …

Glucocorticoids (GC), produced and released by the adrenal glands, regulate numerous
physiological processes in a wide range of tissues. Because of their profound …

Given the significant impact the use of glucocorticoids can have on fracture risk independent
of bone density, their use has been incorporated as one of the clinical risk factors for …

The skeletal effects of inhaled glucocorticoids are poorly understood. Children with asthma
treated with inhaled glucocorticoids have lower growth velocity, bone density, and adult …

Background. Patients using higher dosages of inhaled or oral glucocorticoids (GCs) have an
increased risk of hip/femur fractures. The role of the underlying disease in the aetiology of …

Osteoporosis, through its association with fragility fracture, is a major public health problem,
costing an estimated $34.8 billion worldwide per annum. With projected demographic …