Circadian rhythms in neurodegenerative disorders

M Nassan, A Videnovic - Nature Reviews Neurology, 2022 - nature.com
Endogenous biological clocks, orchestrated by the suprachiasmatic nucleus, time the
circadian rhythms that synchronize physiological and behavioural functions in humans. The …

Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models

SJ Webster, AD Bachstetter, PT Nelson… - Frontiers in …, 2014 - frontiersin.org
The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …

'The clocks that time us'—circadian rhythms in neurodegenerative disorders

A Videnovic, AS Lazar, RA Barker… - Nature Reviews …, 2014 - nature.com
Circadian rhythms are physiological and behavioural cycles generated by an endogenous
biological clock, the suprachiasmatic nucleus. The circadian system influences the majority …

Circadian disruption and sleep disorders in neurodegeneration

Y Shen, Q Lv, W Xie, S Gong, S Zhuang, J Liu… - Translational …, 2023 - Springer
Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative
diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional …

Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathology

L Niu, F Zhang, X Xu, Y Yang, S Li, H Liu… - Brain …, 2022 - Wiley Online Library
Circadian disruption is prevalent in Alzheimer's disease (AD) and may contribute to
cognitive impairment, psychological symptoms, and neurodegeneration. This study aimed to …

Metabolic and non-cognitive manifestations of Alzheimer's disease: the hypothalamus as both culprit and target of pathology

M Ishii, C Iadecola - Cell metabolism, 2015 - cell.com
Alzheimer's disease (AD) is increasingly recognized as a complex neurodegenerative
disease beginning decades prior to the cognitive decline. While cognitive deficits remain the …

A growing link between circadian rhythms, type 2 diabetes mellitus and Alzheimer's disease

X Peng, R Fan, L Xie, X Shi, K Dong, S Zhang… - International journal of …, 2022 - mdpi.com
Type 2 diabetes mellitus (T2DM) patients are at a higher risk of developing Alzheimer's
disease (AD). Mounting evidence suggests the emerging important role of circadian rhythms …

The pathophysiology of restricted repetitive behavior

M Lewis, SJ Kim - Journal of neurodevelopmental disorders, 2009 - Springer
Restricted, repetitive behaviors (RRBs) are heterogeneous ranging from stereotypic body
movements to rituals to restricted interests. RRBs are most strongly associated with autism …

The circadian system in Alzheimer's disease: disturbances, mechanisms, and opportunities

AN Coogan, B Schutová, S Husung, K Furczyk… - Biological …, 2013 - Elsevier
Alzheimer's disease (AD) is a devastating neurodegenerative condition associated with
severe cognitive and behavioral impairments. Circadian rhythms are recurring cycles that …

Modeling behavioral and neuronal symptoms of Alzheimer's disease in mice: a role for intraneuronal amyloid

L Gimenez-Llort, G Blazquez, T Canete… - Neuroscience & …, 2007 - Elsevier
The amyloid Aβ-peptide (Aβ) is suspected to play a critical role in the cascade leading to AD
as the pathogen that causes neuronal and synaptic dysfunction and, eventually, cell death …