Circadian rhythms in neurodegenerative disorders
M Nassan, A Videnovic - Nature Reviews Neurology, 2022 - nature.com
Endogenous biological clocks, orchestrated by the suprachiasmatic nucleus, time the
circadian rhythms that synchronize physiological and behavioural functions in humans. The …
circadian rhythms that synchronize physiological and behavioural functions in humans. The …
Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models
The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …
'The clocks that time us'—circadian rhythms in neurodegenerative disorders
Circadian rhythms are physiological and behavioural cycles generated by an endogenous
biological clock, the suprachiasmatic nucleus. The circadian system influences the majority …
biological clock, the suprachiasmatic nucleus. The circadian system influences the majority …
Circadian disruption and sleep disorders in neurodegeneration
Y Shen, Q Lv, W Xie, S Gong, S Zhuang, J Liu… - Translational …, 2023 - Springer
Disruptions of circadian rhythms and sleep cycles are common among neurodegenerative
diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional …
diseases and can occur at multiple levels. Accumulating evidence reveals a bidirectional …
Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathology
L Niu, F Zhang, X Xu, Y Yang, S Li, H Liu… - Brain …, 2022 - Wiley Online Library
Circadian disruption is prevalent in Alzheimer's disease (AD) and may contribute to
cognitive impairment, psychological symptoms, and neurodegeneration. This study aimed to …
cognitive impairment, psychological symptoms, and neurodegeneration. This study aimed to …
Metabolic and non-cognitive manifestations of Alzheimer's disease: the hypothalamus as both culprit and target of pathology
M Ishii, C Iadecola - Cell metabolism, 2015 - cell.com
Alzheimer's disease (AD) is increasingly recognized as a complex neurodegenerative
disease beginning decades prior to the cognitive decline. While cognitive deficits remain the …
disease beginning decades prior to the cognitive decline. While cognitive deficits remain the …
A growing link between circadian rhythms, type 2 diabetes mellitus and Alzheimer's disease
X Peng, R Fan, L Xie, X Shi, K Dong, S Zhang… - International journal of …, 2022 - mdpi.com
Type 2 diabetes mellitus (T2DM) patients are at a higher risk of developing Alzheimer's
disease (AD). Mounting evidence suggests the emerging important role of circadian rhythms …
disease (AD). Mounting evidence suggests the emerging important role of circadian rhythms …
The pathophysiology of restricted repetitive behavior
M Lewis, SJ Kim - Journal of neurodevelopmental disorders, 2009 - Springer
Restricted, repetitive behaviors (RRBs) are heterogeneous ranging from stereotypic body
movements to rituals to restricted interests. RRBs are most strongly associated with autism …
movements to rituals to restricted interests. RRBs are most strongly associated with autism …
The circadian system in Alzheimer's disease: disturbances, mechanisms, and opportunities
AN Coogan, B Schutová, S Husung, K Furczyk… - Biological …, 2013 - Elsevier
Alzheimer's disease (AD) is a devastating neurodegenerative condition associated with
severe cognitive and behavioral impairments. Circadian rhythms are recurring cycles that …
severe cognitive and behavioral impairments. Circadian rhythms are recurring cycles that …
Modeling behavioral and neuronal symptoms of Alzheimer's disease in mice: a role for intraneuronal amyloid
L Gimenez-Llort, G Blazquez, T Canete… - Neuroscience & …, 2007 - Elsevier
The amyloid Aβ-peptide (Aβ) is suspected to play a critical role in the cascade leading to AD
as the pathogen that causes neuronal and synaptic dysfunction and, eventually, cell death …
as the pathogen that causes neuronal and synaptic dysfunction and, eventually, cell death …