Abstract Emodin (1, 3, 8-trihydroxy-6-methyl-anthraquinone) is a natural anthraquinone
derivative that is present in numerous globally renowned herbal medicines. It is recognised …

Fibrotic diseases are characterized by net accumulation of extracellular matrix proteins in
affected organs leading to their dysfunction and ultimate failure. Myofibroblasts have been …

Inhalation of silica particles is an environmental and occupational cause of silicosis, a type
of pneumoconiosis. Development of the lung silicosis is a unique process in which the …

Acute lung injury (ALI) and its severe manifestation of acute respiratory distress syndrome
(ARDS) are well-known illnesses. Uncontrolled and self-amplified pulmonary inflammation …

Desmoplastic tumors have an abundance of stromal cells and the extracellular matrix which
usually result in therapeutic resistance. Current treatment prescriptions for desmoplastic …

In this study, we investigated the effects of astragaloside IV (As-IV) on pulmonary fibrosis
and its mechanisms of action. Sprague-Dawley rats were used in a model of pulmonary …

Background Idiopathic pulmonary fibrosis (IPF) can severely damage lung function, which
may result in death. Emodin is a major ingredient of rhubarb and has been proven to protect …

Aberrant activation of TGF-β1 is frequently encountered and promotes epithelial-
mesenchymal transition (EMT) and fibroblast activation in pulmonary fibrosis. The present …

Herbal compounds including those already well-established in traditional Chinese medicine
have been increasingly tested in the treatment of various diseases. Recent studies have …

A condition of scarring of lung tissue due to a wide range of causes (such as environmental
pollution, cigarette smoking (CS), lung diseases, some medications, etc.) has been reported …