The International Knockout Mouse Consortium (IKMC) introduces its targeted constructs into
C57BL/6N embryonic stem cells. However, breeding with a Cre-recombinase and/or Flp …

Special features of glucose metabolism in pancreatic β-cells are central to an understanding
of the physiological role of these cells in glucose homeostasis. Several of these …

This article provides an updated overview of the plethora of complex I inhibitors. The
inhibitors are presented within the broad categories of natural and commercial compounds …

Glucose metabolism in glycolysis and in mitochondria is pivotal to glucose-induced insulin
secretion from pancreatic β cells. One or more factors derived from glycolysis other than …

The appropriate secretion of insulin from pancreatic β-cells is critically important to the
maintenance of energy homeostasis. The β-cells must sense and respond suitably to …

Sulphonylureas have been used for over 50 years to enhance insulin secretion in patients
with Type II (non-insulin-dependent) diabetes mellitus but their therapeutic target was not …

In pancreatic β-cells, glucose metabolism signals insulin secretion by altering the cellular
array of messenger molecules. ATP is particularly important, given its role in regulating …

Dunne, Mark J., Karen E. Cosgrove, Ruth M. Shepherd, Albert Aynsley-Green, and Keith J.
Lindley. Hyperinsulinism in Infancy: From Basic Science to Clinical Disease. Physiol Rev 84 …

Uncoupling protein 2 (UCP-2) mRNA expression has been shown to be altered by metabolic
conditions such as obesity in humans, but its functional significance is unknown. The …

Terrorism laws and legal practices have been politically and socially controversial to a
degree beyond almost any other legal issue during the past decade, and this analytical text …