The impact of stress and major depressive disorder on hippocampal and medial prefrontal cortex morphology
EL Belleau, MT Treadway, DA Pizzagalli - Biological psychiatry, 2019 - Elsevier
Volumetric reductions in the hippocampus and medial prefrontal cortex (mPFC) are among
the most well-documented neural abnormalities in major depressive disorder (MDD) …
the most well-documented neural abnormalities in major depressive disorder (MDD) …
Targeting glutamate signalling in depression: progress and prospects
Major depressive disorder (MDD) is severely disabling, and current treatments have limited
efficacy. The glutamate N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine was …
efficacy. The glutamate N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine was …
Inflammation, glutamate, and glia: a trio of trouble in mood disorders
Increasing data indicate that inflammation and alterations in glutamate neurotransmission
are two novel pathways to pathophysiology in mood disorders. The primary goal of this …
are two novel pathways to pathophysiology in mood disorders. The primary goal of this …
Pathogenesis of depression: insights from human and rodent studies
Major depressive disorder (MDD) will affect one out of every five people in their lifetime and
is the leading cause of disability worldwide. Nevertheless, mechanisms associated with the …
is the leading cause of disability worldwide. Nevertheless, mechanisms associated with the …
Brain NMDA receptors in schizophrenia and depression
A Adell - Biomolecules, 2020 - mdpi.com
N-methyl-D-aspartate (NMDA) receptor antagonists such as phencyclidine (PCP),
dizocilpine (MK-801) and ketamine have long been considered a model of schizophrenia …
dizocilpine (MK-801) and ketamine have long been considered a model of schizophrenia …
The neurobiology of depression, ketamine and rapid-acting antidepressants: Is it glutamate inhibition or activation?
The discovery of the antidepressant effects of ketamine has opened a breakthrough
opportunity to develop a truly novel class of safe, effective, and rapid-acting antidepressants …
opportunity to develop a truly novel class of safe, effective, and rapid-acting antidepressants …
Microglial NLRP3 inflammasome activation mediates IL-1β-related inflammation in prefrontal cortex of depressive rats
Y Pan, XY Chen, QY Zhang, LD Kong - Brain, behavior, and immunity, 2014 - Elsevier
Depression is an inflammatory disorder. Pro-inflammatory cytokine interleukin-1 beta (IL-1β)
may play a pivotal role in the central nervous system (CNS) inflammation of depression …
may play a pivotal role in the central nervous system (CNS) inflammation of depression …
Stratification of astrocytes in healthy and diseased brain
Astrocytes, a subtype of glial cells, come in variety of forms and functions. However,
overarching role of these cell is in the homeostasis of the brain, be that regulation of ions …
overarching role of these cell is in the homeostasis of the brain, be that regulation of ions …
Caffeine acts through neuronal adenosine A2A receptors to prevent mood and memory dysfunction triggered by chronic stress
MP Kaster, NJ Machado, HB Silva… - Proceedings of the …, 2015 - National Acad Sciences
The consumption of caffeine (an adenosine receptor antagonist) correlates inversely with
depression and memory deterioration, and adenosine A2A receptor (A2AR) antagonists …
depression and memory deterioration, and adenosine A2A receptor (A2AR) antagonists …
Menin deficiency leads to depressive-like behaviors in mice by modulating astrocyte-mediated neuroinflammation
Astrocyte dysfunction and inflammation are associated with the pathogenesis of major
depressive disorder (MDD). However, the mechanisms underlying these effects remain …
depressive disorder (MDD). However, the mechanisms underlying these effects remain …