Chronic hepatitis C is one of the most widespread liver diseases in the world, with over 170
million individuals infected with the hepatitis C virus (HCV). Several clinical studies have …

Hypoxia is a common phenomenon in solid tumours and is considered a hallmark of cancer.
Increasing evidence shows that hypoxia promotes local immune suppression. Type I IFN is …

Solids with deformation-diffusion coupling are ubiquitous in engineering applications.
Understanding and modeling the fracture of such solids is vitally important. This thesis …

Viruses are dependent on the metabolic machinery of the host cell to supply the energy and
molecular building blocks needed for their replication. Substantial research has focused on …

Hypoxia has been linked to the pathogenesis of hepatic steatosis in murine and human
models. There is an abundance of data suggesting that HIFs play a central role in regulating …

La biologie de l'oxygène est bien étudiée depuis 60 ans en cancérologie pour pallier à la
résistance des tumeurs solides à la chimiothérapie et la radiothérapie. Les travaux de …

The life cycle of HCV involves a dysregulation in host lipid metabolism that may precede
metabolic complications such as insulin resistance (IR), type 2 diabetes mellitus (T2DM) …

Bien que linflammation soit essentielle pour le remodelage des réponses immunitaires et le
contrôle des infections, elle est souvent associée à la pathogenèse lors des maladies …

Bovine respiratory disease (BRD) is a multi-factorial inflammatory respiratory disease
complex and is a significant problem for the beef industry. While the infectious agents …

The Plcsmodium liver stage is an attractive target for the development of antimalarial drugs
and vaccines, as it provides an opportunity to interrupt the life cycle of the parasite at a …