Prime editing: advances and therapeutic applications

Z Zhao, P Shang, P Mohanraju, N Geijsen - Trends in Biotechnology, 2023 - cell.com
Clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR–
Cas)-mediated genome editing has revolutionized biomedical research and will likely …

Advances in CRISPR-based SERS detection of food contaminants: a review

M Hajikhani, Y Zhang, X Gao, M Lin - Trends in Food Science & …, 2023 - Elsevier
Background The integration of CRISPR-Cas systems and surface-enhanced Raman
spectroscopy (SERS) has emerged as a powerful approach for developing highly sensitive …

Viral Vectors for the in Vivo Delivery of CRISPR Components: Advances and Challenges

M Asmamaw Mengstie - Frontiers in Bioengineering and …, 2022 - frontiersin.org
The Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) and its
accompanying protein (Cas9) are now the most effective, efficient, and precise genome …

CRISPR-based genome editing for nutrient enrichment in crops: a promising approach toward global food security

D Kumar, A Yadav, R Ahmad, UN Dwivedi… - Frontiers in …, 2022 - frontiersin.org
The global malnutrition burden imparts long-term developmental, economic, social, and
medical consequences to individuals, communities, and countries. The current …

Industrial applications of fungal lipases: a review

A Kumar, V Verma, VK Dubey, A Srivastava… - Frontiers in …, 2023 - frontiersin.org
Fungal lipases (triacylglycerol acyl hydrolases EC 3.1. 1.3) are significant industrial
enzymes and have several applications in a number of industries and fields. Fungal lipases …

Gene editing therapeutics based on mRNA delivery

J Popovitz, R Sharma, R Hoshyar, BS Kim… - Advanced Drug Delivery …, 2023 - Elsevier
The field of gene editing has received much attention in recent years due to its immense
therapeutic potential. In particular, gene editing therapeutics, such as the CRISPR-Cas …

Viral vectors and extracellular vesicles: innate delivery systems utilized in CRISPR/Cas-mediated cancer therapy

SE Ahmadi, M Soleymani, F Shahriyary… - Cancer Gene …, 2023 - nature.com
Gene editing-based therapeutic strategies grant the power to override cell machinery and
alter faulty genes contributing to disease development like cancer. Nowadays, the principal …

Flourishing tumor organoids: History, emerging technology, and application

Q Yang, M Li, X Yang, Z Xiao, X Tong… - Bioengineering & …, 2023 - Wiley Online Library
Malignant tumors are one of the leading causes of death which impose an increasingly
heavy burden on all countries. Therefore, the establishment of research models that closely …

CRISPR/Cas9 assisted stem cell therapy in Parkinson's disease

P Pinjala, KP Tryphena, R Prasad, DK Khatri… - Biomaterials …, 2023 - Springer
Since its discovery in 2012, CRISPR Cas9 has been tried as a direct treatment approach to
correct the causative gene mutation and establish animal models in neurodegenerative …

[HTML][HTML] Reduction of biofilm formation of Escherichia coli by targeting quorum sensing and adhesion genes using the CRISPR/Cas9-HDR approach, and its clinical …

M Alshammari, A Ahmad, M AlKhulaifi… - Journal of Infection and …, 2023 - Elsevier
Background Escherichia coli is a common cause of biofilm-associated urinary tract infections
(UTIs). Biofilm formation in E. coli is responsible for various indwelling medical device …