Low dose buprenorphine initiation, is an alternative method of initiating buprenorphine in
which the starting dose is very low and gradually increased to therapeutic levels over a …

Opioid use disorder (OUD) is a treatable chronic disorder with episodes of remission and
recurrence characterized by loss of control of opioid use, compulsive use, and continued …

Objectives: Buprenorphine can precipitate withdrawal in opioid-dependent persons with
recent fentanyl use. However, the prevalence of this phenomenon is not clinically …

Increased orexin/hypocretin signaling is implicated in opioid withdrawal, sleep disturbances,
and drug-seeking behaviors. This study examined whether a dual-orexin receptor …

Importance Buprenorphine treatment for opioid use disorder (OUD) has more than doubled
since 2009. However, current US Food and Drug Administration buprenorphine dosing …

Introduction The illicit opioid supply in the US is increasingly adulterated with fentanyl. As
such, persons with opioid use disorder (OUD) may be regularly exposed to fentanyl …

Background Induction of buprenorphine, an evidence-based treatment for opioid use
disorder (OUD), has been reported to be difficult for people with heavy use of fentanyl, the …

Objectives This narrative review summarizes literature on pharmaceutical fentanyl's
absorption, distribution, metabolism, and excretion patterns to inform research on illicitly …

Drug markets are dynamic systems which change based on demand, competition,
legislation and revenue. Shifts that are not met with immediate and appropriate responses …

Buprenorphine induction for treating opioid use disorder is being implemented in
emergency care. During this era of high-potency synthetic opioid use, novel and divergent …