The activity of voltage-gated sodium channels has long been linked to disorders of neuronal
excitability such as epilepsy and chronic pain. Recent genetic studies have now expanded …

Misfolded proteins compromise cellular homeostasis. This is especially problematic in the
endoplasmic reticulum (ER), which is a high-capacity protein-folding compartment and …

Mutations in SCN2A, a gene encoding the voltage-gated sodium channel Nav1. 2, have
been associated with a spectrum of epilepsies and neurodevelopmental disorders. Here, we …

Late I Na is an integral part of the sodium current, which persists long after the fast-
inactivating component. The magnitude of the late I Na is relatively small in all species and …

Voltage-gated sodium channels (VGSC) are multi-molecular protein complexes expressed
in both excitable and non-excitable cells. They are primarily formed by a pore-forming multi …

A variety of ion channels have been detected in cancer cells. In particular, upregulation of
voltage-gated sodium channels (VGSCs) has been associated pathophysiologically with …

Voltage-gated sodium channels (VGSC) play important roles in the development and
progression of many cancers. We report the possible roles of VGSC in human ovarian …

Voltage-gated sodium channels are abnormally expressed in tumors, often as neonatal
isoforms, while they are not expressed, or only at a low level, in the matching normal tissue …

A range of experimental and clinical data suggests strongly (i) that metastatic progression in
carcinomas is accompanied (maybe even preceded) by upregulation of functional voltage …

Familial hemiplegic migraine (FHM) is a rare subtype of migraine with aura. Mutations
causing FHM type 3 have been identified in SCN1A, the gene encoding the Nav1. 1 Na+ …