[HTML][HTML] Poor birth outcomes in malaria in pregnancy: recent insights into mechanisms and prevention approaches
Pregnant women in malaria-endemic regions are susceptible to malaria in pregnancy, which
has adverse consequences on birth outcomes, including having small for gestational age …
has adverse consequences on birth outcomes, including having small for gestational age …
[HTML][HTML] Progress and insights toward an effective placental malaria vaccine
B Gamain, A Chêne, NK Viebig… - Frontiers in …, 2021 - frontiersin.org
In areas where Plasmodium falciparum transmission is endemic, clinical immunity against
malaria is progressively acquired during childhood and adults are usually protected against …
malaria is progressively acquired during childhood and adults are usually protected against …
PRIMVAC vaccine adjuvanted with Alhydrogel or GLA-SE to prevent placental malaria: a first-in-human, randomised, double-blind, placebo-controlled study
SB Sirima, L Richert, A Chêne, AT Konate… - The Lancet Infectious …, 2020 - thelancet.com
Background PRIMVAC is a VAR2CSA-derived placental malaria vaccine candidate aiming
to prevent serious clinical outcomes of Plasmodium falciparum infection during pregnancy …
to prevent serious clinical outcomes of Plasmodium falciparum infection during pregnancy …
[HTML][HTML] Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA
R Ma, T Lian, R Huang, JP Renn, JD Petersen… - Nature …, 2021 - nature.com
Plasmodium falciparum VAR2CSA binds to chondroitin sulfate A (CSA) on the surface of the
syncytiotrophoblast during placental malaria. This interaction facilitates placental …
syncytiotrophoblast during placental malaria. This interaction facilitates placental …
[HTML][HTML] Structure-guided design of VAR2CSA-based immunogens and a cocktail strategy for a placental malaria vaccine
R Ma, ND Salinas, S Orr-Gonzalez… - PLoS …, 2024 - journals.plos.org
Placental accumulation of Plasmodium falciparum infected erythrocytes results in maternal
anemia, low birth weight, and pregnancy loss. The parasite protein VAR2CSA facilitates the …
anemia, low birth weight, and pregnancy loss. The parasite protein VAR2CSA facilitates the …
[HTML][HTML] The delay in the licensing of protozoal vaccines: a comparative history
CB Palatnik-de-Sousa, D Nico - Frontiers in Immunology, 2020 - frontiersin.org
Although viruses and bacteria have been known as agents of diseases since 1546, 250
years went by until the first vaccines against these pathogens were developed (1796 and …
years went by until the first vaccines against these pathogens were developed (1796 and …
[HTML][HTML] Placental malaria vaccine candidate antigen VAR2CSA displays atypical domain architecture in some Plasmodium falciparum strains
JYA Doritchamou, R Morrison, JP Renn… - Communications …, 2019 - nature.com
Two vaccines based on Plasmodium falciparum protein VAR2CSA are currently in clinical
evaluation to prevent placental malaria (PM), but a deeper understanding of var2csa …
evaluation to prevent placental malaria (PM), but a deeper understanding of var2csa …
A single full-length VAR2CSA ectodomain variant purifies broadly neutralizing antibodies against placental malaria isolates
JYA Doritchamou, JP Renn, B Jenkins, A Mahamar… - Elife, 2022 - elifesciences.org
Placental malaria (PM) is a deadly syndrome most frequent and severe in first pregnancies.
PM results from accumulation of Plasmodium falciparum-infected erythrocytes (IE) that …
PM results from accumulation of Plasmodium falciparum-infected erythrocytes (IE) that …
[HTML][HTML] Preclinical immunogenicity and safety of the cGMP-grade placental malaria vaccine PRIMVAC
A Chêne, S Gangnard, A Guadall, H Ginisty, O Leroy… - …, 2019 - thelancet.com
Background VAR2CSA is the lead antigen for developing a vaccine that would protect
pregnant women against placental malaria. A multi-system feasibility study has identified E …
pregnant women against placental malaria. A multi-system feasibility study has identified E …
[HTML][HTML] A conserved epitope in VAR2CSA is targeted by a cross-reactive antibody originating from Plasmodium vivax Duffy binding protein
During Plasmodium falciparum infection in pregnancy, VAR2CSA is expressed on the
surface of infected erythrocytes (IEs) and mediates their sequestration in the placenta. As a …
surface of infected erythrocytes (IEs) and mediates their sequestration in the placenta. As a …