This narrative review examines the possible role of microglial cells, first, in
neuroinflammation and, second, in schizophrenia, depression, and suicide. Recent research …

Schizophrenia is a psychiatric disorder with significant impact on individuals and society.
The current pharmacologic treatment, which principally alleviates psychosis, is focused on …

Microglia, the immune cells of the brain, are important for neurodevelopment and have been
hypothesized to play a role in the pathogenesis of schizophrenia (SCZ). Although previous …

An increasing number of clinical, epidemiological and genetic studies as well as
investigations of CSF and blood suggests that neuroinflammation plays an essential role in …

Cognitive impairment is a core clinical feature of schizophrenia, exerting profound adverse
effects on social functioning and quality of life in a large proportion of patients with …

Background Bipolar disorder (BD) is associated with marked functional impairments along
with increased rate of suicide. Although there is ample evidence for the involvement of …

There have been a large number of reports about glial cell dysfunction being related to
major psychiatric diseases such as schizophrenia (SCZ), bipolar disorder (BD), and major …

Bipolar disorder (BD) is a severe and multifactorial disease, with onset usually in young
adulthood, which follows a progressive course throughout life. Replicated epidemiological …

Suicide is a complex public health challenge associated worldwide with one death every 40
s. Research advances in the neuropathology of suicidal behaviors (SB) have defined …

Abstract Changes in immune function are associated with variance in cognitive functioning
in schizophrenia. Given that microglia are the primary innate immune cells in the brain, we …