The blood vessel wall has a number of self‐healing properties, enabling it to minimize blood
loss and prevent or overcome infections in the event of vascular trauma. Endothelial cells …

Vascular endothelial cells produce and release compounds regulating vascular tone, blood
vessel growth and differentiation, plasma composition, coagulation and fibrinolysis, and also …

The vascular environment can rapidly alter, and the speed with which responses to both
physiological and pathological changes are required necessitates the existence of a highly …

Integrins are transmembrane receptors that transduce biochemical and mechanical signals
across the plasma membrane and promote cell adhesion and migration. In addition, integrin …

Cellular communication relies on fusion of secretory vesicles with the plasma membrane,
following dynamic events that change the micro-and nanoscale environment of the …

Nonmuscle myosin II is an actin-based motor that executes numerous mechanical tasks in
cells including spatiotemporal organization of the actin cytoskeleton, adhesion, migration …

Backgrounds As a systemic skeletal dysfunction, osteoporosis (OP) is characterized by low
bone mass and bone microarchitectural damage. The global incidences of OP are high …

Agonist-mediated exocytosis of Weibel-Palade bodies underpins the endothelium's ability to
respond to injury or infection. Much of this important response is mediated by the major …

Cellular secretion depends on exocytosis of secretory vesicles and discharge of vesicle
contents. Actin and myosin are essential for pre-fusion and post-fusion stages of exocytosis …

Essentials• Endothelial activation initiates multiple processes, including hemostasis and
inflammation.• The molecules that contribute to these processes are co‐stored in secretory …