Over the past 20 years, the zebrafish has emerged as a powerful model organism for
studying cardiac development. Its ability to survive without an active circulation and …

The Zebrafish has emerged to become a powerful vertebrate animal model for
cardiovascular research in recent years. Its advantages include easy genetic manipulation …

Defects in cardiac valve morphogenesis and septation of the heart chambers constitute
some of the most common human congenital abnormalities. Some of these defects originate …

Vertebrate hearts depend on highly specialized cardiomyocytes that form the cardiac
conduction system (CCS) to coordinate chamber contraction and drive blood efficiently and …

Over the course of development, the vertebrate heart undergoes a series of complex
morphogenetic processes that transforms it from a simple myocardial epithelium to the …

The mesenchymal-to-epithelial transition (MET) is an intrinsically mechanical process
describing a multi-step progression where autonomous mesenchymal cells gradually …

Elongation of the vertebrate heart occurs by progressive addition of second heart field (SHF)
cardiac progenitor cells from pharyngeal mesoderm to the poles of the heart tube. The …

Msx1 and Msx2 are highly conserved, Nk-related homeodomain transcription factors that are
essential for a variety of tissue–tissue interactions during vertebrate organogenesis. Here …

Extracellular matrix (ECM) remodeling is critical for organogenesis, yet its molecular
regulation is poorly understood. In zebrafish, asymmetric migration of the epithelial lateral …

An outstanding problem in vertebrate development has been to define the genetic program
that specifies the cardiomyocyte lineage. It has been a challenge to define the transcription …