Cardiac fibrosis critically injured the cardiac structure and function of the hypertensive
patients. However, the anti‐fibrotic strategy is still far from satisfaction. This study aims to …

Arterial hypertension is a cardiovascular disease that leads to important systemic alterations
and drastically impairs normal organ function over time. Hypertension affects around 700 …

Essential hypertension is the leading cause of premature death worldwide. However,
hypertension's cause remains uncertain. endoplasmic reticulum (ER) stress has recently …

Numerous studies on the effects of antihypertensive treatment in young spontaneously
hypertensive rats (SHRs) have shown that early-onset therapy may effectively reduce their …

The aim of the present study was to evaluate the effect of low-dose spironolactone initiated
during the early stages of hypertension development and to assess the effects of chronic …

Spontaneously hypertensive rats (SHR) are an established animal model for
antihypertensive treatment. The aim of this pilot study was a systematic search for two lines …

Left ventricular hypertrophy (LVH) is a major adaptative response to the increase in the
overload produced by hypertension, is a risk factor for myocardial infarction, stroke, and …

Background: A major problem in the treatment of human hypertension is the late diagnosis
of hypertension and, hence, the delayed start of treatment. Very often, hypertension has …

OBJECTIVE: To evaluate the effect of spironolactone on ventricular stiffness in
spontaneously hypertensive adult rats subjected to high salt intake. INTRODUCTION: High …

Background: Captopril, an angiotensin-converting enzyme inhibitor, and losartan, an
angiotensin II receptor blocker, are used for the treatment of hypertension, but their effects …