Initially thought to be useful only to reach tissues in the immediate vicinity of the CSF
circulatory system, CSF circulation is now increasingly viewed as a viable pathway to deliver …

Background The spinal subarachnoid space (SSS) has a complex 3D fluid-filled geometry
with multiple levels of anatomic complexity, the most salient features being the spinal cord …

Cerebrospinal fluid (CSF) dynamics are thought to play a vital role in central nervous system
(CNS) physiology. The objective of this study was to investigate the impact of spinal cord …

Background Developing novel therapeutic agents to treat amyotrophic lateral sclerosis
(ALS) has been difficult due to multifactorial pathophysiologic processes at work. Intrathecal …

The movement of cerebrospinal fluid (CSF) is linked to the cardiovascular and respiratory
systems. The heart not only drives blood flow but is also at the origin of CSF pulsation …

The motion of the cerebrospinal fluid in the spinal subarachnoid space, a slender annular
canal surrounding the spinal cord, exhibits an oscillatory velocity component driven by the …

Recent advancements have been made toward understanding the diagnostic and
therapeutic potential of cerebrospinal fluid (CSF) and related hydrodynamics. Increased …

Background Blood removal from cerebrospinal fluid (CSF) in post-subarachnoid
hemorrhage patients may reduce the risk of related secondary brain injury. We formulated a …

Background Syringomyelia is a pathological condition in which fluid-filled cavities (syringes)
form and expand in the spinal cord. Syringomyelia is often linked with obstruction of the …

It has been hypothesized that early and rapid filtration of blood from cerebrospinal fluid
(CSF) in postsubarachnoid hemorrhage patients may reduce hospital stay and related …