Astrocytes in chronic pain and itch
Astrocytes are critical for maintaining the homeostasis of the CNS. Increasing evidence
suggests that a number of neurological and neuropsychiatric disorders, including chronic …
suggests that a number of neurological and neuropsychiatric disorders, including chronic …
Cognitive behavioral therapy for chronic insomnia: a systematic review and meta-analysis
Background: Because psychological approaches are likely to produce sustained benefits
without the risk for tolerance or adverse effects associated with pharmacologic approaches …
without the risk for tolerance or adverse effects associated with pharmacologic approaches …
Cognitive behavioral therapy for insomnia in patients with chronic pain–a systematic review and meta-analysis of randomized controlled trials
Several randomized controlled trials have implemented cognitive behavioral therapy for
insomnia (CBT-I) for patients with comorbid insomnia and chronic pain. This systematic …
insomnia (CBT-I) for patients with comorbid insomnia and chronic pain. This systematic …
[HTML][HTML] The association of sleep and pain: an update and a path forward
Ample evidence suggests that sleep and pain are related. However, many questions remain
about the direction of causality in their association, as well as mechanisms that may account …
about the direction of causality in their association, as well as mechanisms that may account …
[HTML][HTML] Assessment of psychosocial and functional impact of chronic pain
The psychosocial and functional consequences of chronic pain disorders have been well
documented as having significant effects on the experience of pain, presentation to health …
documented as having significant effects on the experience of pain, presentation to health …
Sleep disturbances and sleep disorders in adults living with chronic pain: a meta-analysis
JL Mathias, ML Cant, ALJ Burke - Sleep medicine, 2018 - Elsevier
Objectives Chronic pain, with or without an identified diagnosis or cause, is widespread and
commonly associated with sleep disturbances. However, research has often used poor …
commonly associated with sleep disturbances. However, research has often used poor …
Chronic insomnia
CM Morin, R Benca - The Lancet, 2012 - thelancet.com
Insomnia is a prevalent complaint in clinical practice that can present independently or
comorbidly with another medical or psychiatric disorder. In either case, it might need …
comorbidly with another medical or psychiatric disorder. In either case, it might need …
The burden of chronic low back pain: clinical comorbidities, treatment patterns, and health care costs in usual care settings
Study Design. Retrospective analysis of an insurance claims database. Objective. To
examine the comorbidities, treatment patterns, health care resource utilization, and direct …
examine the comorbidities, treatment patterns, health care resource utilization, and direct …
Sleep loss and inflammation
JM Mullington, NS Simpson, HK Meier-Ewert… - Best practice & research …, 2010 - Elsevier
Controlled, experimental studies on the effects of acute sleep loss in humans have shown
that mediators of inflammation are altered by sleep loss. Elevations in these mediators have …
that mediators of inflammation are altered by sleep loss. Elevations in these mediators have …
[HTML][HTML] Effects of sleep changes on pain-related health outcomes in the general population: a systematic review of longitudinal studies with exploratory meta-analysis
Emerging longitudinal research has highlighted poor sleep as a risk factor of a range of
adverse health outcomes, including disabling pain conditions. In establishing the causal role …
adverse health outcomes, including disabling pain conditions. In establishing the causal role …