Childhood maltreatment represents a form of trauma capable of altering fundamental
neurobiological properties and negatively impacting neurodevelopmental processes. An …

Importance Associations between adverse childhood experiences (ACEs) and chronic
diseases among middle-aged or older Chinese individuals have not been well documented …

There is continued interest in identifying dysregulated biomarkers that mediate associations
between adverse childhood experiences (ACEs) and negative long-term health outcomes …

Background Research has consistently shown a relationship between adverse childhood
experiences (ACEs) and poor mental health outcomes, and recent research shows that …

Background Building on decades of research into the long-term developmental impacts of
adverse childhood experiences (ACEs), researchers have called for expanding the ACEs …

Rising and economically disproportionate rates of adverse mental health outcomes among
children and youth warrant research investigating the complex pathways stemming from …

Major depressive disorder (MDD) is a highly heterogeneous disorder, which may partly
explain why treatment outcome using antidepressants is unsatisfactory. We investigated the …

The theory that oxidative damage caused by mitochondrial free radicals leads to aging has
brought mitochondria into the forefront of aging research. Psychological stress that …

Adverse childhood experiences (ACEs) are linked to poorer mental health outcomes, and
growing evidence implicates biological and genetic pathways from early adversity to …

Exposure to early life stress (ELS) is associated with a variety of detrimental psychological
and neurodevelopmental effects. Importantly, ELS has been associated with regional …