[HTML][HTML] The role of calmodulin in tumor cell migration, invasiveness, and metastasis
A Villalobo, MW Berchtold - International Journal of Molecular Sciences, 2020 - mdpi.com
Calmodulin (CaM) is the principal Ca2+ sensor protein in all eukaryotic cells, that upon
binding to target proteins transduces signals encoded by global or subcellular-specific …
binding to target proteins transduces signals encoded by global or subcellular-specific …
[HTML][HTML] Role of metalloproteases in the CD95 signaling pathways
L Devel, N Guedeney, S Bregant… - Frontiers in …, 2022 - frontiersin.org
CD95L (also known as FasL or CD178) is a member of the tumor necrosis family (TNF)
superfamily. Although this transmembrane ligand has been mainly considered as a potent …
superfamily. Although this transmembrane ligand has been mainly considered as a potent …
[HTML][HTML] Glioblastoma cells vampirize WNT from neurons and trigger a JNK/MMP signaling loop that enhances glioblastoma progression and neurodegeneration
M Portela, V Venkataramani, N Fahey-Lozano… - PLoS …, 2019 - journals.plos.org
Glioblastoma (GB) is the most lethal brain tumor, and Wingless (Wg)-related integration site
(WNT) pathway activation in these tumors is associated with a poor prognosis. Clinically, the …
(WNT) pathway activation in these tumors is associated with a poor prognosis. Clinically, the …
[HTML][HTML] The influence of race/ethnicity on the transcriptomic landscape of uterine fibroids
TD Chuang, N Ton, S Rysling, D Quintanilla… - International journal of …, 2023 - mdpi.com
The objective of this study was to determine if the aberrant expression of select genes could
form the basis for the racial disparity in fibroid characteristics. The next-generation RNA …
form the basis for the racial disparity in fibroid characteristics. The next-generation RNA …
[HTML][HTML] Matrix metalloproteinases: how much can they do?
MS Ågren, U auf dem Keller - International journal of molecular sciences, 2020 - mdpi.com
Zinc-dependent matrix metalloproteinases (MMPs) belong to metzincins that comprise not
only 23 human MMPs but also other metalloproteinases, such as 21 human ADAMs (a …
only 23 human MMPs but also other metalloproteinases, such as 21 human ADAMs (a …
[HTML][HTML] Matrix metalloproteinases as biomarkers and therapeutic targets in colitis-associated cancer
N Sampaio Moura, A Schledwitz, M Alizadeh… - Frontiers in …, 2024 - frontiersin.org
Colorectal cancer (CRC) remains a major cause of morbidity and mortality. Therapeutic
approaches for advanced CRC are limited and rarely provide long-term benefit. Enzymes …
approaches for advanced CRC are limited and rarely provide long-term benefit. Enzymes …
Novel matrix metalloproteinase inhibitors: an updated patent review (2014-2020)
ABSTRACT Introduction: Matrix MetalloProteinases (MMPs) are key enzymes in several
pathophysiological processes connected to the extracellular matrix (ECM) degradation …
pathophysiological processes connected to the extracellular matrix (ECM) degradation …
[HTML][HTML] A newly defined basement membrane-related gene signature for the prognosis of clear-cell renal cell carcinoma
T Zhou, W Chen, Z Wu, J Cai, C Zhou - Frontiers in genetics, 2022 - frontiersin.org
Background: Basement membranes (BMs) are associated with cell polarity, differentiation,
migration, and survival. Previous studies have shown that BMs play a key role in the …
migration, and survival. Previous studies have shown that BMs play a key role in the …
Emerging roles of MTMMPs in embryonic development
N Moracho, AIR Learte, E MuñozSáez… - Developmental …, 2022 - Wiley Online Library
Membranetype matrix metalloproteinases (MTMMPs) are cell membranetethered
proteinases that belong to the family of the MMPs. Apart from their roles in degradation of the …
proteinases that belong to the family of the MMPs. Apart from their roles in degradation of the …
[HTML][HTML] Src activation in lipid rafts confers epithelial cells with invasive potential to escape from apical extrusion during cell competition
Abnormal/cancerous cells within healthy epithelial tissues undergo apical extrusion to
protect against carcinogenesis, although they acquire invasive capacity once …
protect against carcinogenesis, although they acquire invasive capacity once …