Pulmonary toxicity, including fibrosis, is a serious adverse effect associated with the
antidysrhythmic drug amiodarone (AM). We tested the potential usefulness of pirfenidone …

The accumulation mechanisms of amiodarone (AMD) involving transporters in lung alveolar
epithelial type II cells were studied. The uptake of AMD was examined using human alveolar …

Amiodarone (AM) is a potent and efficacious antidysrhythmic agent that can cause
potentially life-threatening pulmonary fibrosis. Vitamin E has been demonstrated to …

Amiodarone (AM), an antidysrrhythmic drug, can produce serious adverse effects, including
potentially fatal AM-induced pulmonary toxicity (AIPT). AM-induced cytotoxicity and …

Amiodarone (AD) is gaining support as a first-line antiarrhythmic drug despite its potentially
fatal pulmonary toxicity involving inflammation and fibrosis. The goals of this study were to …

MATERIALS AND METHODS Chemicals AMD and DEA were kindly supplied by Taisho
Pharmaceutical (Tokyo, Japan). All other reagents were of the highest grade available and …

Amiodarone (AD) is gaining support as a first-line antiarrhythmic drug despite its potentially
fatal pulmonary toxicity involving inflammation and fibrosis. We previously reported a model …

Amiodarone (AD) has been shown to produce a transient pulmonary fibrosis in hamsters
after intratracheal (it) instillation. The goal of this study was to examine bronchoalveolar …

Brief exposure to cigarette smoke is not generally associated with pulmonary injury and may
adversely affect the lung only if underlying disease is present. To test this hypothesis, our …

Although the role of oxidative stress has recently been the subject of increased discussion in
relation to the pathogenesis of amiodarone (AMIO) toxicity, the cellular mechanisms …