Androgens are an important and diverse group of steroid hormone molecular species. They
play varied functional roles, such as the control of metabolic energy fate and partition, the …

Prostate cancer (PCa) is a prevalent malignancy that occurs primarily in old males. Prostate
tumors in different patients manifest significant inter-patient heterogeneity with respect to …

Sex steroids are major promoters of the growth of breast and prostate cancers. This Review
by Poutanen et al. describes the development of treatments for these cancer types that act to …

The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …

All aspects of prostate cancer evolution are closely related to androgen levels and the status
of the androgen receptor (AR). Almost all treatments target androgen metabolism pathways …

The discovery of the benefits of castration for prostate cancer treatment in 1941 led to
androgen deprivation therapy, which remains a mainstay of the treatment of men with …

Mutations of the androgen receptor (AR) associated with prostate cancer and androgen
insensitivity syndrome may profoundly influence its structure, protein interaction network …

Simple Summary Approximately 1 in 8 men will be diagnosed with prostate cancer (PCa) at
some point in their lifetime. Five-year survival rate for patients with local or regionally spread …

Among anabolic agents, selective androgen receptor modulators (SARMs) represent a new
class of potential drugs that can exhibit anabolic effects on muscle and bone with reduced …

Hepatocellular carcinoma (HCC) is a major global health problem that often correlates with
poor prognosis. Due to the insufficient therapy options with limited benefits, it is crucial to …