A central aspect of the pathogenesis of gout is elevated urate concentrations, which lead to
the formation of monosodium urate crystals. The clinical features of gout result from an …

Hyperuricemia, or elevated serum urate, causes urate kidney stones and gout and also
increases the incidence of many other conditions including renal disease, cardiovascular …

Thyroid dysfunction is an important public health problem, which affects 10% of the general
population and increases the risk of cardiovascular morbidity and mortality. Many aspects of …

The remote sensing and signaling hypothesis provides a useful systems-level framework for
understanding the complex interplay of uric acid transporters expressed in different tissues …

Uric acid metabolic disorder is considered to be the main pathogenesis of uric acid
nephropathy (UN). Smilax glabra Roxb. is a traditional Chinese herb which has been used …

Although many genome-wide association studies (GWASs) of hyperuricemia or gout have
been reported, the related genetic factors and the mechanisms from hyperuricemia to gouty …

This study was designed to investigate the effects and underlying mechanisms of
Astaxanthin (AST) on high-fructose-induced hyperuricemia (HUA) from the perspectives of …

The regulation of hepatic gene expression has been extensively studied at the
transcriptional level; however, the control of metabolism through posttranscriptional gene …

Gout is a common of inflammatory arthritis and is caused by the deposition of monosodium
urate (MSU) crystals as a result of hyperuricemia (HUA). Although HUA is considered to be …

Studies examining associations between purine metabolites and type 2 diabetes (T2D) are
limited. We prospectively examined associations between plasma levels of purine …