The precise molecular mechanisms by which urate-associated genetic variants affect urate
levels are unknown. Here, we tested for functional linkage of the maximally associated …

Hyperuricemia and gout are complex diseases mediated by genetic, epigenetic, and
environmental exposure interactions. The incidence and medical burden of gout, an …

There is a paucity of genome-wide association study on Han Chinese gout patients. We
performed a genome-wide association meta-analysis on two Taiwanese cohorts consisting …

Metabolic disorders are a group of interrelated conditions which increases the risk of
developing heart diseases, stroke, and diabetes. These usually occur as a consequence of …

Advances in gout genetics have provided important molecular insights into disease
pathogenesis, better characterized the pharmacogenetics of allopurinol, and raised the …

Gout is a common form of inflammatory arthritis caused by hyperuricemia and the deposition
of Monosodium Urate (MSU) crystals. It is also considered as a complex disorder in which …

高尿酸血症(HUA) 是人体内尿酸生成和排泄稳态失调从而导致血清尿酸水平升高超过参考范围
的一类异质性疾病. 既往研究发现3 个常见尿酸转运蛋白基因(ABCG2, SLC2A9 和SLC22A12) …

Studies have shown that genetic variations can influence metabolic response to nutrient
intake, and that diets rich in fructose contribute to hyperuricemia. In this pilot study, our aim …

Gout—a very painful inflammatory arthritis caused by the deposition of monosodium urate
crystals in the joints—is influenced by several factors. We identified the association of single …

Uric acid is a product of purine degradation, and uric acid may have multiple physiologic
roles, including the beneficial effects as an antioxidant and neuroprotector, maintenance of …