The ancient biological'arms race'between microbial pathogens and humans has shaped
genetic variation in modern populations, and this has important implications for the growing …

Most of the human pandemics reported to date can be classified as zoonoses. Among these,
there is a long history of infectious diseases that have spread from non-human primates …

Linkage disequilibrium—the nonrandom association of alleles at different loci—is a sensitive
indicator of the population genetic forces that structure a genome. Because of the explosive …

There are approximately 800 annotated G protein–coupled receptor (GPCR) genes, making
these membrane receptors members of the most abundant gene family in the human …

The ability to detect recent natural selection in the human population would have profound
implications for the study of human history and for medicine. Here, we introduce a framework …

▪ Abstract In addition to CD4, the human immunodeficiency virus (HIV) requires a coreceptor
for entry into target cells. The chemokine receptors CXCR4 and CCR5, members of the G …

Human Evolutionary Genetics is a groundbreaking text which for the first time brings
together molecular genetics and genomics to the study of the origins and movements of …

Pathogens have always been a major cause of human mortality, so they impose strong
selective pressure on the human genome. Data from population genetic studies, including …

In most human populations, the ability to digest lactose contained in milk usually disappears
in childhood, but in European-derived populations, lactase activity frequently persists into …

A debate has recently arisen over the use of racial classification in medicine and biomedical
research. In particular, with the completion of a rough draft of the human genome, some …