Tanshinone IIA (Tan IIA) is a pharmacologically lipophilic active constituent isolated from the
roots and rhizomes of the Chinese medicinal herb Salvia miltiorrhiza Bunge (Danshen). Tan …

Purpose Growing solid tumors mostly outstrip blood supply and become hypoxic (low
oxygen supply). To survive under this pathological milieu, tumors overexpress a potent …

In a previous study, we demonstrated that Tanshinone IIA effectively inhibits CRC
angiogenesis in vivo, but the underlying mechanisms were not elucidated. In this report, we …

Despite significant technological advancements in conventional therapies, cancer remains
one of the main causes of death worldwide. Although substantial progress has been made …

The search for natural and efficacious antineoplastic drugs, with minimal toxicity and side
effects, is an important part of antitumor drug research and development. Tanshinone IIA is …

Danshen (salvia miltiorrhiza Bunge) is widely used in traditional Chinese medicine.
However, it is definite clinical effort and mechanism on breast cancer is unclear. In our study …

Hypoxia-inducible factor 1 (HIF-1) plays a pivotal role in tumor adaptation to
microenvironmental hypoxia, and it also exerts important roles in angiogenesis and tumor …

Breast cancer is the major cause of deaths in women worldwide. Detection and treatment of
breast cancer at earlier stages of the disease has shown encouraging results. Modern …

Cancer is a common malignant disease worldwide with an increasing mortality in recent
years. Salvia miltiorrhiza, a well-known traditional Chinese medicine, has been used for the …

Extensive research over the past decades has identified numerous phytochemicals that
could represent an important source of anti-cancer compounds. There is an immediate need …