Hyponatremia is the most common electrolyte disorder, affecting more than 15% of patients
in the hospital. Syndrome of inappropriate antidiuresis (SIAD) is the most frequent cause of …

The osmolality of body fluids is normally maintained within a narrow range. This constancy is
achieved largely via hypothalamic osmoreceptors that regulate thirst and arginine …

Transsphenoidal surgery is the first-line treatment for many clinically significant pituitary
tumors and sellar lesions. Although complication rates are low when performed at high …

Adrenocortical insufficiency causes difficulty in diagnosis and morbidity out of proportion to
its rarity, because of the non-specific, multi-system nature of the clinical features. Most of …

Hyponatremia is the most frequently occurring electrolyte abnormality and can lead to life-
threatening complications. This disorder may be present on admission to the intensive care …

Hyponatremia is the most common electrolyte disturbance seen in clinical practice, affecting
up to 30% of acute hospital admissions, and is associated with significant adverse clinical …

The maintenance of the tonicity of body fluids within a narrow physiologic range is made
possible by homeostatic mechanisms that control the intake and excretion of water …

Hypertonic saline was infused into 11 volunteers to osmotically stimulate vasopressin
secretion. A strong positive correlation between plasma arginine vasopressin (PAVP) and …

Methods Male Sprague-Dawley (SD) rats and male rats of the Brattleboro strain with
hereditary hypothalamic diabetes insipidus (DI), each weighing 150 to 200 g, were used for …

Celebrating more than twenty years as the single best source in the field, this Fifth Edition
has now expanded into two cornerstone volumes with 53 fully inclusive chapters and 73 …