One carbon metabolism (OCM) is critical for early development, as it provides one carbon
(1C) units for the biosynthesis of DNA, proteins, and lipids and epigenetic modification of the …

Folate is a dietary micronutrient essential to one-carbon metabolism. The World Health
Organisation recommends folic acid (FA) supplementation pre-conception and in early …

Pancreatic beta cells play a central role in regulating glucose homeostasis by secreting the
hormone insulin. Failure of beta cells due to reduced function and mass and the resulting …

This review delves into the intricate relationship between excess folate (vitamin B9) intake,
especially its synthetic form, namely, folic acid, and its implications on health and disease …

Insulin resistance (IR) is largely recognized as a unifying feature that underlies metabolic
dysfunction. Both lifestyle and genetic factors contribute to IR. Work from recent years has …

Food fortification with synthetic folic acid (FA), along with supplementation, results in a
marked increase in the population total of serum folates and unmetabolized folic acid …

Fructooligosaccharide (FOS) is fermented by intestinal microbes to generate intestinal
microbe-derived hydrogen gas (IMDH). Oxidative stress increases during gestation …

The role of folate, in its synthetic and bioactive form, as an in utero modifier of metabolic
outcomes in mothers and offspring is examined in this review. During pregnancy, a …

The prevalences of diabetes mellitus and obesity are increasing yearly and has become a
serious social burden. In addition to genetic factors, environmental factors in early life …

Folate, also known as vitamin B9, facilitates the transfer of methyl groups among molecules,
which is crucial for amino acid metabolism and nucleotide synthesis. Adequate maternal …