Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …

Key Clinical Points Abdominal Aortic Aneurysms Abdominal aortic aneurysms are usually
asymptomatic until they rupture, with an ensuing mortality of 85 to 90%. Symptomatic …

Matrix metalloproteinase‐9 (MMP‐9) belongs to the MMP family and has been widely
investigated. Excessive MMP‐9 expression can enhance extracellular matrix degradation …

Background Community screening to guide preventive interventions for acute aortic disease
has been recommended in high‐risk individuals. We sought to prospectively assess risk …

Background: Long noncoding RNAs have emerged as critical molecular regulators in
various biological processes and diseases. Here we sought to identify and functionally …

Rationale: Uncontrolled growth of abdominal aortic aneurysms (AAAs) is a life-threatening
vascular disease without an effective pharmaceutical treatment. AAA incidence dramatically …

Objective—Sclerostin (SOST) has been identified as an important regulator of bone
formation; however, it has not been previously implicated in arterial disease. The aim of this …

Background An abdominal aortic aneurysm (AAA) is an abnormal ballooning of the major
abdominal artery. Some AAAs present as emergencies and require surgery; others remain …

Background It has been suggested that diabetes medications, such as metformin, may have
effects that inhibit abdominal aortic aneurysm (AAA) growth. The aim of this study was to …

The matrix metalloproteinases (MMPs) are 23 secreted or cell surface proteases that act
together and with other protease classes to turn over the extracellular matrix, cleave cell …