In vitro acute and developmental neurotoxicity screening: an overview of cellular platforms and high-throughput technical possibilities
BZ Schmidt, M Lehmann, S Gutbier, E Nembo… - Archives of …, 2017 - Springer
Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard
assessment. Since the interpretation of animal data and their extrapolation to man is …
assessment. Since the interpretation of animal data and their extrapolation to man is …
Bioprinting of human pluripotent stem cells and their directed differentiation into hepatocyte-like cells for the generation of mini-livers in 3D
A Faulkner-Jones, C Fyfe, DJ Cornelissen… - …, 2015 - iopscience.iop.org
We report the first investigation into the bioprinting of human induced pluripotent stem cells
(hiPSCs), their response to a valve-based printing process as well as their post-printing …
(hiPSCs), their response to a valve-based printing process as well as their post-printing …
[HTML][HTML] Recent policies that support clinical application of induced pluripotent stem cell-based regenerative therapies
K Azuma, S Yamanaka - Regenerative Therapy, 2016 - Elsevier
In Japan, a research center network consisting of Kyoto University to provide clinical-grade
induced Pluripotent Stem Cells (iPSC) and several major research centers to develop iPSC …
induced Pluripotent Stem Cells (iPSC) and several major research centers to develop iPSC …
Advanced good cell culture practice for human primary, stem cell-derived and organoid models as well as microphysiological systems
A major reason for the current reproducibility crisis in the life sciences is the poor
implementation of quality control measures and reporting standards. Improvement is …
implementation of quality control measures and reporting standards. Improvement is …
Stem cell-derived immature human dorsal root ganglia neurons to identify peripheral neurotoxicants
L Hoelting, S Klima, C Karreman… - Stem Cells …, 2016 - academic.oup.com
Safety sciences and the identification of chemical hazards have been seen as one of the
most immediate practical applications of human pluripotent stem cell technology. Protocols …
most immediate practical applications of human pluripotent stem cell technology. Protocols …
A bioprinted heart-on-a-chip with human pluripotent stem cell-derived cardiomyocytes for drug evaluation
A Faulkner-Jones, V Zamora, MP Hortigon-Vinagre… - Bioengineering, 2022 - mdpi.com
In this work, we show that valve-based bioprinting induces no measurable detrimental
effects on human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). The …
effects on human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). The …
Thorough QT/QTc in a Dish: An In Vitro Human Model That Accurately Predicts Clinical Concentration‐QTc Relationships
AD Blanchette, FA Grimm, C Dalaijamts… - Clinical …, 2019 - Wiley Online Library
“Thorough QT/corrected QT (QTc)”(TQT) studies are cornerstones of clinical cardiovascular
safety assessment. However, TQT studies are resource intensive, and preclinical models …
safety assessment. However, TQT studies are resource intensive, and preclinical models …
[HTML][HTML] The use of induced pluripotent stem cells for the study and treatment of liver diseases
Liver disease is a major global health concern. Liver cirrhosis is one of the leading causes of
death in the world and currently the only therapeutic option for end-stage liver disease (eg …
death in the world and currently the only therapeutic option for end-stage liver disease (eg …
Cell death assays for neurodegenerative disease drug discovery
JW Linsley, T Reisine, S Finkbeiner - Expert opinion on drug …, 2019 - Taylor & Francis
Introduction: Neurodegenerative diseases affect millions of people worldwide.
Neurodegeneration is gradual over time, characterized by neuronal death that causes …
Neurodegeneration is gradual over time, characterized by neuronal death that causes …
Safety lead optimization and candidate identification: integrating new technologies into decision-making
DM Dambach, D Misner, M Brock… - Chemical research in …, 2016 - ACS Publications
Discovery toxicology focuses on the identification of the most promising drug candidates
through the development and implementation of lead optimization strategies and hypothesis …
through the development and implementation of lead optimization strategies and hypothesis …