Intestinal drug permeability has been recognized as a critical determinant of the fraction
dose absorbed, with direct influence on bioavailability, bioequivalence and biowaiver. The …

The heterogeneity of the Caco-2 cell line and differences in experimental protocols for
permeability assessment using this cell-based method have resulted in the high variability of …

BCS classification is a vital tool in the development of both generic and innovative drug
products. The purpose of this work was to provisionally classify the world's top selling oral …

Rifaximin is a BCS class IV (low-solubility, low-permeability) drug and also a P-gp substrate.
The aims of this work were to assess the efficiency of different rifaximin amorphous solid …

Hydrotropy refers to increasing the water solubility of otherwise poorly soluble compound by
the presence of small organic molecules. While it can certainly increase the apparent …

Since the publication of Lindenberg et al., which classified orally administered active
pharmaceutical ingredients (APIs) on the 2004 Essential Medicines List (EML) of the World …

Although recognized as overly conservative, metoprolol is currently the common low/high
BCS permeability class boundary reference compound, while labetalol was suggested as a …

The main objective of this work was to investigate in-silico predictions of physicochemical
properties, in order to guide oral drug development by provisional biopharmaceutics …

The preparation of amorphous solid dispersions (ASDs) is a suitable approach to overcome
solubility-limited absorption of poorly soluble drugs. In particular, pH-dependent soluble …

Introduction: Drug discovery is the process of designing new candidate medications for the
treatment of diseases. Over many years, drugs have been identified serendipitously …