The purpose of this work was to investigate the use of the dimethylaminoethyl methacrylate-
copolymer Eudragit EPO (EPO) in oral solubility-enabling formulations for anionic lipophilic …

Small molecule developability challenges have been well documented over the last two
decades. One of these critical developability parameters is aqueous solubility. In general …

This article summarizes historic developments, recent expert opinions, and (currently)
unresolved challenges concerning the Biopharmaceutics Classification System (BCS) …

Colon microbiota-based drug metabolism has received little attention thus far in the process
of drug development, whereas the role of gut microbiota in clinical safety and efficacy of …

Two different synthetic approaches to novel heterocyclic hybrid compounds of 4-
azapodophyllotoxin were investigated. The obtained products were characterized by …

Traditionally, the colon is considered a secondary intestinal segment in the drug absorption
process. However, in many cases the role of colonic drug permeability cannot be …

The first aim of this study was to evaluate the usefulness of optimized human fecal material
in simulating sulforeductase activity in the lower intestine by assessing bacterial degradation …

The aim of the present study is to contribute to the scientific characterization of sildenafil
citrate according to the Biopharmaceutics Classification System, following the World Health …

The present monograph reviews data relevant to applying the biowaiver procedure for the
approval of immediate-release multisource solid dosage forms containing codeine …

The developmental origin of health and diseases theory supports the critical role of the fetal
exposure to children's health. We developed a physiologically based pharmacokinetic …