Background A shift towards higher molecular weight (MW) of drug candidates is anticipated
to lead to changed pharmacokinetics (PK), including deteriorated absorption. Methods The …

Abstract Highly ordered hexagonal (MCM-41) mesoporous silica nanoparticles (MSNs)
loaded with etoposide (ETO) were synthesized and functionalized with amino groups (MCM …

El siguiente trabajo tiene como objetivos clasificar los ingredientes farmacéuticos activos
(IFAs) de los sólidos orales de liberación inmediata del Cuadro Básico de Medicamentos de …

Purpose A dataset of fraction excreted unchanged in the urine (fe) values was developed
and used to evaluate the ability of preclinical animal species to predict high urinary …

Cell culture permeability experiments are valuable tools in drug development and candidate
selection, but the monolayer preparation protocols and the calculations procedures can …

Introduction Various in vitro methods are used to measure absorption, distribution,
metabolism and excretion/pharmacokinetics (ADME/PK) of candidate drugs and predict and …

Abstract A series of seventeen novel hydroxamic acids incorporating 1-((1 H-1, 2, 3-triazol-4-
yl) methyl)-3-hydroxyimino-indolin-2-ones was designed and synthesized. Biological …

The biopharmaceutical classification system (BCS) is now well established and utilized for
the development and biowaivers of immediate oral dosage forms. The prediction of BCS …

Purpose To examine the utility of human plasma as an assay medium in Caco-2
permeability studies to overcome poor mass balance and inadequate sink conditions …

Theoretically, the risk of food effects for extended-release (ER) products compared to IR
products may be less because:(1) postprandial physiological changes are usually transient …