Neutrophil recruitment in pneumococcal pneumonia

CS Palmer, JM Kimmey - Frontiers in Cellular and Infection …, 2022 - frontiersin.org
Streptococcus pneumoniae (Spn) is the primary agent of community-acquired pneumonia.
Neutrophils are innate immune cells that are essential for bacterial clearance during …

Oxidative stress and cancer heterogeneity orchestrate NRF2 roles relevant for therapy response

K Gall Trošelj, M Tomljanović, M Jaganjac… - Molecules, 2022 - mdpi.com
Oxidative stress and its end-products, such as 4-hydroxynonenal (HNE), initiate activation of
the Nuclear Factor Erythroid 2-Related Factor 2 (NRF2)/Kelch Like ECH Associated Protein …

The role of platelets in the regulation of tumor growth and metastasis: the mechanisms and targeted therapy

K Liao, X Zhang, J Liu, F Teng, Y He, J Cheng… - MedComm, 2023 - Wiley Online Library
Platelets are a class of pluripotent cells that, in addition to hemostasis and maintaining
vascular endothelial integrity, are also involved in tumor growth and distant metastasis. The …

The acidic tumour microenvironment: Manipulating the immune response to elicit escape

CM Worsley, RB Veale, ES Mayne - Human Immunology, 2022 - Elsevier
The success of cancer treatment relies on the composition of the tumour microenvironment
which is comprised of tumour cells, blood vessels, stromal cells, immune cells, and …

Multifunctional nanosystems powered photodynamic immunotherapy

Y Ma, F Xiao, C Lu, L Wen - Frontiers in Pharmacology, 2022 - frontiersin.org
Photodynamic Therapy (PDT) with the intrinsic advantages including non-invasiveness,
spatiotemporal selectivity, low side-effects, and immune activation ability has been clinically …

IL-1β in breast cancer bone metastasis

J Zhou, C Tulotta, PD Ottewell - Expert Reviews in Molecular …, 2022 - cambridge.org
Bone is the most common site for advanced breast cancer to metastasise. The
proinflammatory cytokine, interleukin-1β (IL-1β) plays a complex and contradictory role in …

Neutrophil N1 and N2 subsets and their possible association with periodontitis: a scoping review

LD Sansores-España, S Melgar-Rodríguez… - International Journal of …, 2022 - mdpi.com
Periodontitis is a chronic non-communicable disease caused by dysbiotic changes that
affect the subgingival microbiota. During periodontitis, neutrophils play a central role in the …

Electrospun fiber-based strategies for controlling early innate immune cell responses: towards immunomodulatory mesh designs that facilitate robust tissue repair

D Venugopal, S Vishwakarma, I Kaur, S Samavedi - Acta Biomaterialia, 2023 - Elsevier
Electrospun fibrous meshes are widely used for tissue repair due to their ability to guide a
host of cell responses including phenotypic differentiation and tissue maturation. A critical …

Impact of the Cancer Cell Secretome in driving breast Cancer progression

S Zahari, SE Syafruddin, MA Mohtar - Cancers, 2023 - mdpi.com
Simple Summary Breast cancer is a complex disease that remains a significant public health
challenge. The breast cancer cells secrete various substances collectively known as the …

Immune cell plasticity in inflammation: Insights into description and regulation of immune cell phenotypes

A Margraf, M Perretti - Cells, 2022 - mdpi.com
Inflammation is a life-saving immune reaction occurring in response to invading pathogens.
Nonetheless, inflammation can also occur in an uncontrolled, unrestricted manner, leading …