Objective: Recently, the characteristic longitudinal distribution pattern of the underlying
phosphorylated TDP-43 (pTDP-43) pathology in the behavioral variant of frontotemporal …

Neuropathological studies revealed the propagation of amyotrophic lateral sclerosis (ALS)
in a sequence of four separate disease-related regional patterns. Diffusion tensor imaging …

An innovative approach to patient management, evidence-based policy development, and
clinical drug trials is required to provide personalized care and to improve the likelihood of …

Objective This study aimed to explore the clinical significance of brain imaging signatures in
the context of clinical neurological deficits in association with upper and lower motor neuron …

Background There is an ongoing debate about the concept of restricted phenotypes of
amyotrophic lateral sclerosis (ALS), including progressive bulbar palsy (PBP). Objective The …

Neuroimaging assessment of motor neuron disease has turned into a cornerstone of its
clinical workup. Amyotrophic lateral sclerosis (ALS), as a paradigmatic motor neuron …

Introduction Diffusion tensor imaging (DTI) can be used to map disease progression in
amyotrophic lateral sclerosis (ALS) and therefore is a promising candidate for a biomarker in …

Background: The regional distribution of the widespread cerebral morphological alterations
in progressive supranuclear palsy (PSP) is considered to include segmental parts of the …

Objective: Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder
predominantly affecting the motor system. In a number of patients, mirror movements (MMs) …

Background Increased catabolism has recently been recognized as a clinical manifestation
of amyotrophic lateral sclerosis (ALS). The hypothalamic systems have been shown to be …