Subcortical pathology is known to be highly prevalent in dementia and motor
neurodegenerative conditions, however, how these subcortical changes impact on disease …

Background: The regional distribution of the widespread cerebral morphological alterations
in progressive supranuclear palsy (PSP) is considered to include segmental parts of the …

Motor neuron dysfunctions (MNDys) in Frontotemporal Lobar Degeneration (FTLD) have
been consistently reported. Clinical and neurophysiological findings proved a variable …

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disorder
characterized by the loss of both upper and lower motor neurons. Studies using metrics …

Background ALS patients with hexanucleotide expansion in C9orf72 are characterized by a
specific clinical phenotype, including more aggressive disease course and cognitive …

Background Degenerative myelopathy (DM) in dogs shares similarities with superoxide
dismutase 1‐associated human amyotrophic lateral sclerosis (ALS). Brain microstructural …

Objective This study aimed to explore the clinical significance of brain imaging signatures in
the context of clinical neurological deficits in association with upper and lower motor neuron …

Neuroimaging is a valuable adjunct to the history and examination in the evaluation of motor
system disorders. Conventional imaging with computed tomography or magnetic resonance …

Background Longitudinal brain MRI monitoring in neurodegeneration potentially provides
substantial insights into the temporal dynamics of the underlying biological process, but is …

Amyotrophic lateral sclerosis (ALS) is a fatal progressive neurodegenerative disease that
causes degeneration of both upper and lower motor neurons primarily affecting the motor …