Photoreceptor cells and RPE contribute to the development of diabetic retinopathy

D Tonade, TS Kern - Progress in retinal and eye research, 2021 - Elsevier
Diabetic retinopathy (DR) is a leading cause of blindness. It has long been regarded as
vascular disease, but work in the past years has shown abnormalities also in the neural …

[HTML][HTML] Genome editing in the treatment of ocular diseases

EH Choi, S Suh, AE Sears, R Hołubowicz… - … & molecular medicine, 2023 - nature.com
Genome-editing technologies have ushered in a new era in gene therapy, providing novel
therapeutic strategies for a wide range of diseases, including both genetic and nongenetic …

[HTML][HTML] In vivo imaging of the human eye using a 2-photon-excited fluorescence scanning laser ophthalmoscope

J Boguslawski, G Palczewska… - The Journal of …, 2022 - Am Soc Clin Investig
Background Noninvasive assessment of metabolic processes that sustain regeneration of
human retinal visual pigments (visual cycle) is essential to improve ophthalmic diagnostics …

[PDF][PDF] Rapid RGR-dependent visual pigment recycling is mediated by the RPE and specialized Müller glia

A Tworak, AV Kolesnikov, JD Hong, EH Choi, JC Luu… - Cell reports, 2023 - cell.com
In daylight, demand for visual chromophore (11-cis-retinal) exceeds supply by the classical
visual cycle. This shortfall is compensated, in part, by the retinal G-protein-coupled receptor …

From mouse to human: Accessing the biochemistry of vision in vivo by two-photon excitation

G Palczewska, M Wojtkowski, K Palczewski - Progress in retinal and eye …, 2023 - Elsevier
The eye is an ideal organ for imaging by a multi-photon excitation approach, because ocular
tissues such as the sclera, cornea, lens and neurosensory retina, are highly transparent to …

Optogenetic strategies for high-efficiency all-optical interrogation using blue-light-sensitive opsins

A Forli, M Pisoni, Y Printz, O Yizhar, T Fellin - Elife, 2021 - elifesciences.org
All-optical methods for imaging and manipulating brain networks with high spatial resolution
are fundamental to study how neuronal ensembles drive behavior. Stimulation of neuronal …

Benchmarking two-photon absorption strengths of rhodopsin chromophore models with CC3 and CCSD methodologies: An assessment of popular density functional …

S Sirimatayanant, T Andruniów - The Journal of Chemical Physics, 2023 - pubs.aip.org
This work presents the investigations of the impact of an increasing electron correlation in
the hierarchy of coupled-cluster methods, ie, CC2, CCSD, and CC3, on two-photon …

In situ autofluorescence lifetime assay of a photoreceptor stimulus response in mouse retina and human retinal organoids

K Samimi, BR Pattnaik, EE Capowski… - Biomedical Optics …, 2022 - opg.optica.org
Photoreceptors are the key functional cell types responsible for the initiation of vision in the
retina. Phototransduction involves isomerization and conversion of vitamin A compounds …

Laser-induced deformation and fragmentation of droplets in an array

DCK Rao, AP Singh, S Basu - International Journal of Multiphase Flow, 2022 - Elsevier
Droplet–droplet interactions is ubiquitous in various applications ranging from medical
diagnostics to enhancing and optimizing liquid jet propulsion. We employ an experimental …

Secondary cavitation bubble dynamics during laser-induced bubble formation in a small container

L Fu, J Wang, S Wang, Z Zhang, A Vogel, X Liang… - Optics …, 2024 - opg.optica.org
We investigated secondary cavitation bubble dynamics during laser-induced bubble
formation in a small container with a partially confined free surface and elastic thin walls. We …