The physiological functions of human peroxisomes
RJA Wanders, M Baes, D Ribeiro… - Physiological …, 2023 - journals.physiology.org
Peroxisomes are subcellular organelles that play a central role in human physiology by
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …
Plasmalogens: A potential therapeutic target for neurodegenerative and cardiometabolic disease
Plasmalogens are a class of membrane glycerophospholipids with unique properties. They
contain a vinyl-ether linked alkyl chain at the sn-1 position of the glycerol backbone and …
contain a vinyl-ether linked alkyl chain at the sn-1 position of the glycerol backbone and …
[HTML][HTML] Genetic screen for cell fitness in high or low oxygen highlights mitochondrial and lipid metabolism
Human cells are able to sense and adapt to variations in oxygen levels. Historically, much
research in this field has focused on hypoxia-inducible factor (HIF) signaling and reactive …
research in this field has focused on hypoxia-inducible factor (HIF) signaling and reactive …
From peroxisomal disorders to common neurodegenerative diseases–the role of ether phospholipids in the nervous system
F Dorninger, S Forss‐Petter, J Berger - FEBS letters, 2017 - Wiley Online Library
The emerging diverse roles of ether (phospho) lipids in nervous system development and
function in health and disease are currently attracting growing interest. Plasmalogens, a …
function in health and disease are currently attracting growing interest. Plasmalogens, a …
Squalene monooxygenase: a journey to the heart of cholesterol synthesis
Squalene monooxygenase (SM) is a vital sterol synthesis enzyme across eukaryotic life. In
yeast, it is a therapeutic target for treating certain fungal infections, and in mammals it is a …
yeast, it is a therapeutic target for treating certain fungal infections, and in mammals it is a …
On the road to unraveling the molecular functions of ether lipids
N Jiménez‐Rojo, H Riezman - FEBS letters, 2019 - Wiley Online Library
Ether lipids are glycerolipids further classified into alkyl‐ether and alkenyl‐ether (also
termed plasmalogens) lipids. The two ether lipid subclasses share the first steps of their …
termed plasmalogens) lipids. The two ether lipid subclasses share the first steps of their …
Plasmalogen homeostasis–regulation of plasmalogen biosynthesis and its physiological consequence in mammals
M Honsho, Y Fujiki - Febs Letters, 2017 - Wiley Online Library
Plasmalogens, mostly ethanolamine‐containing alkenyl ether phospholipids, are a major
subclass of glycerophospholipids. Plasmalogen synthesis is initiated in peroxisomes and …
subclass of glycerophospholipids. Plasmalogen synthesis is initiated in peroxisomes and …
[HTML][HTML] Chronic inflammation, neuroglial dysfunction, and plasmalogen deficiency as a new pathobiological hypothesis addressing the overlap between post-COVID …
AM Chaves-Filho, O Braniff, A Angelova, Y Deng… - Brain Research …, 2023 - Elsevier
After five waves of coronavirus disease 2019 (COVID-19) outbreaks, it has been recognized
that a significant portion of the affected individuals developed long-term debilitating …
that a significant portion of the affected individuals developed long-term debilitating …
[HTML][HTML] Coronavirus-induced host cubic membranes and lipid-related antiviral therapies: A focus on bioactive plasmalogens
Y Deng, A Angelova - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Coronaviruses have lipid envelopes required for their activity. The fact that coronavirus
infection provokes the formation of cubic membranes (CM)(denoted also as convoluted …
infection provokes the formation of cubic membranes (CM)(denoted also as convoluted …
[HTML][HTML] Population-based plasma lipidomics reveals developmental changes in metabolism and signatures of obesity risk: a mother-offspring cohort study
Background Lipids play a vital role in health and disease, but changes to their circulating
levels and the link with obesity remain poorly characterized in expecting mothers and their …
levels and the link with obesity remain poorly characterized in expecting mothers and their …