The physiological functions of human peroxisomes

RJA Wanders, M Baes, D Ribeiro… - Physiological …, 2023 - journals.physiology.org
Peroxisomes are subcellular organelles that play a central role in human physiology by
catalyzing a range of unique metabolic functions. The importance of peroxisomes for human …

Plasmalogens: A potential therapeutic target for neurodegenerative and cardiometabolic disease

S Paul, GI Lancaster, PJ Meikle - Progress in lipid research, 2019 - Elsevier
Plasmalogens are a class of membrane glycerophospholipids with unique properties. They
contain a vinyl-ether linked alkyl chain at the sn-1 position of the glycerol backbone and …

[HTML][HTML] Genetic screen for cell fitness in high or low oxygen highlights mitochondrial and lipid metabolism

IH Jain, SE Calvo, AL Markhard, OS Skinner, TL To… - Cell, 2020 - cell.com
Human cells are able to sense and adapt to variations in oxygen levels. Historically, much
research in this field has focused on hypoxia-inducible factor (HIF) signaling and reactive …

From peroxisomal disorders to common neurodegenerative diseases–the role of ether phospholipids in the nervous system

F Dorninger, S Forss‐Petter, J Berger - FEBS letters, 2017 - Wiley Online Library
The emerging diverse roles of ether (phospho) lipids in nervous system development and
function in health and disease are currently attracting growing interest. Plasmalogens, a …

Squalene monooxygenase: a journey to the heart of cholesterol synthesis

NK Chua, HW Coates, AJ Brown - Progress in lipid research, 2020 - Elsevier
Squalene monooxygenase (SM) is a vital sterol synthesis enzyme across eukaryotic life. In
yeast, it is a therapeutic target for treating certain fungal infections, and in mammals it is a …

On the road to unraveling the molecular functions of ether lipids

N Jiménez‐Rojo, H Riezman - FEBS letters, 2019 - Wiley Online Library
Ether lipids are glycerolipids further classified into alkyl‐ether and alkenyl‐ether (also
termed plasmalogens) lipids. The two ether lipid subclasses share the first steps of their …

Plasmalogen homeostasis–regulation of plasmalogen biosynthesis and its physiological consequence in mammals

M Honsho, Y Fujiki - Febs Letters, 2017 - Wiley Online Library
Plasmalogens, mostly ethanolamine‐containing alkenyl ether phospholipids, are a major
subclass of glycerophospholipids. Plasmalogen synthesis is initiated in peroxisomes and …

[HTML][HTML] Chronic inflammation, neuroglial dysfunction, and plasmalogen deficiency as a new pathobiological hypothesis addressing the overlap between post-COVID …

AM Chaves-Filho, O Braniff, A Angelova, Y Deng… - Brain Research …, 2023 - Elsevier
After five waves of coronavirus disease 2019 (COVID-19) outbreaks, it has been recognized
that a significant portion of the affected individuals developed long-term debilitating …

[HTML][HTML] Coronavirus-induced host cubic membranes and lipid-related antiviral therapies: A focus on bioactive plasmalogens

Y Deng, A Angelova - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Coronaviruses have lipid envelopes required for their activity. The fact that coronavirus
infection provokes the formation of cubic membranes (CM)(denoted also as convoluted …

[HTML][HTML] Population-based plasma lipidomics reveals developmental changes in metabolism and signatures of obesity risk: a mother-offspring cohort study

SA Mir, L Chen, S Burugupalli, B Burla, S Ji, AAT Smith… - BMC medicine, 2022 - Springer
Background Lipids play a vital role in health and disease, but changes to their circulating
levels and the link with obesity remain poorly characterized in expecting mothers and their …