Depression is associated with dysregulation of methyl group metabolism such as low S-
adenosylmethionine (SAM). We previously reported that Flinders Sensitive Line (FSL) rats …

This is the protocol for an evidence and gap map. The objectives are as follows: To map
available randomized control trials, economic evaluations, and systematic reviews that …

Background Depression is a major health issue in many countries that can negatively affect
the lives of sufferers, their families and communities. There is also significant economic …

Introduction Since the year 2000, over 413,000 service members have sustained traumatic
brain injury (TBI) and may present with post-concussive sequelae including headaches …

Complementary and alternative medicine (CAM) refers to a range of treatments, therapies
and practices that are not considered part of conventional medicine. CAM approaches are …

In previous studies, we produced changes in gene expression in the brain of mice by early
postnatal administration of valproic acid (VPA), with distinct differences between genders …

Pre-menstrual disorders, including pre-menstrual syndrome and pre-menstrual dysphoric
disorder, are highly prevalent disorders in women of reproductive age. Pre-menstrual …

In this narrative review, we intended to summarize the evidence of pharmacological and
somatic treatment choices for treatment-resistant depression (TRD). There are several types …

Methods Nutraceutical-focused systematic reviews and clinical practice guidelines identified
the more commonly studied augmentation strategies for depression. Results S …

Background Complementary and Alternative Medicine (CAM) is commonly and increasingly
used in America and worldwide and can include both pharmacologic (eg, vitamins and …